A circuit perspective on narcolepsy.
cataplexy
hypocretins/orexins
narcolepsy
neural circuits
Journal
Sleep
ISSN: 1550-9109
Titre abrégé: Sleep
Pays: United States
ID NLM: 7809084
Informations de publication
Date de publication:
12 05 2020
12 05 2020
Historique:
received:
20
08
2019
revised:
13
11
2019
pubmed:
11
1
2020
medline:
15
4
2021
entrez:
11
1
2020
Statut:
ppublish
Résumé
The sleep disorder narcolepsy is associated with symptoms related to either boundary state control that include excessive daytime sleepiness and sleep fragmentation, or rapid eye movement (REM) sleep features including cataplexy, sleep paralysis, hallucinations, and sleep-onset REM sleep events (SOREMs). Although the loss of Hypocretin/Orexin (Hcrt/Ox) peptides or their receptors have been associated with the disease, here we propose a circuit perspective of the pathophysiological mechanisms of these narcolepsy symptoms that encompasses brain regions, neuronal circuits, cell types, and transmitters beyond the Hcrt/Ox system. We further discuss future experimental strategies to investigate brain-wide mechanisms of narcolepsy that will be essential for a better understanding and treatment of the disease.
Identifiants
pubmed: 31919524
pii: 5699663
doi: 10.1093/sleep/zsz296
pmc: PMC7215265
pii:
doi:
Substances chimiques
Neuropeptides
0
Orexins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Research Council
ID : 725850
Pays : International
Organisme : NINDS NIH HHS
ID : R01 NS106032
Pays : United States
Organisme : NIDDK NIH HHS
ID : R15 DK105510
Pays : United States
Informations de copyright
© Sleep Research Society 2020. Published by Oxford University Press [on behalf of the Sleep Research Society].
Références
Ann Neurol. 2013 Dec;74(6):794-804
pubmed: 24006291
Front Neurol. 2018 Oct 05;9:790
pubmed: 30344503
Neurobiol Dis. 2018 Dec;120:12-20
pubmed: 30149182
J Neurosci. 2012 Mar 14;32(11):3809-17
pubmed: 22423101
Neuroscience. 2016 Nov 12;336:102-113
pubmed: 27595887
J Neurosci. 2018 Feb 7;38(6):1588-1599
pubmed: 29311142
Sleep. 2010 Mar;33(3):297-306
pubmed: 20337187
Nat Neurosci. 2010 Dec;13(12):1526-33
pubmed: 21037585
Electroencephalogr Clin Neurophysiol. 1985 Jul;61(1):61-70
pubmed: 2408864
Elife. 2015 Oct 01;4:e08638
pubmed: 26426478
Nature. 2005 Sep 22;437(7058):556-9
pubmed: 16100511
Science. 1991 May 31;252(5010):1315-8
pubmed: 1925546
J Comp Neurol. 2018 Dec 15;526(18):2937-2954
pubmed: 30019757
J Neurosci. 2015 Apr 8;35(14):5435-41
pubmed: 25855162
J Neurosci. 2009 Mar 25;29(12):3705-14
pubmed: 19321767
Neurology. 2005 Oct 25;65(8):1184-8
pubmed: 16247044
J Neurosci. 1992 May;12(5):1640-6
pubmed: 1578258
Nat Med. 2000 Sep;6(9):991-7
pubmed: 10973318
Eur J Neurosci. 2012 May;35(9):1426-32
pubmed: 22507526
J Comp Neurol. 2005 Jan 10;481(2):160-78
pubmed: 15562511
J Physiol. 2004 Jan 1;554(Pt 1):202-15
pubmed: 14678502
J Neurosci. 2017 Apr 12;37(15):3995-4006
pubmed: 28235898
Neuron. 2000 Sep;27(3):469-74
pubmed: 11055430
BMC Genomics. 2008 Sep 16;9:418
pubmed: 18796152
Brain Res. 2002 Jul 19;944(1-2):190-4
pubmed: 12106679
eNeuro. 2016 Jun 09;3(3):
pubmed: 27294196
Trends Neurosci. 2006 Oct;29(10):571-7
pubmed: 16904760
Sleep Med. 2011 Sep;12(8):768-72
pubmed: 21697009
Sleep Med Rev. 2017 Apr;32:85-94
pubmed: 27083772
J Comp Neurol. 2006 Feb 10;494(5):845-61
pubmed: 16374809
Sleep. 2018 Jun 1;41(6):
pubmed: 29522212
Neuron. 2005 Apr 21;46(2):297-308
pubmed: 15848807
J Neurosci. 1995 Jul;15(7 Pt 1):4806-14
pubmed: 7623112
Nat Neurosci. 2018 Aug;21(8):1084-1095
pubmed: 30038273
J Neurosci. 2004 Dec 15;24(50):11439-48
pubmed: 15601950
Cell. 1999 Aug 6;98(3):365-76
pubmed: 10458611
J Neurosci. 2012 Sep 5;32(36):12305-11
pubmed: 22956821
Sleep. 1986;9(1 Pt 2):205-15
pubmed: 3704444
J Physiol. 2011 Jun 1;589(Pt 11):2767-79
pubmed: 21486780
Neuroscience. 2002;112(2):355-65
pubmed: 12044453
Nat Commun. 2018 Feb 5;9(1):504
pubmed: 29402935
J Neurosci. 2016 Feb 3;36(5):1747-57
pubmed: 26843654
J Sleep Res. 2016 Oct;25(5):591-595
pubmed: 27230703
Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):322-7
pubmed: 9419374
Neuron. 2003 Jun 5;38(5):715-30
pubmed: 12797957
J Neurosci. 2004 Jun 9;24(23):5336-45
pubmed: 15190106
Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5464-E5473
pubmed: 28630298
Sleep. 2010 Oct;33(10):1295-304
pubmed: 21061851
Lancet. 2000 Jan 1;355(9197):39-40
pubmed: 10615891
Cell Rep. 2014 May 8;7(3):697-704
pubmed: 24767990
J Sleep Res. 2012 Apr;21(2):185-8
pubmed: 21883592
J Neurosci. 2018 Mar 7;38(10):2505-2518
pubmed: 29431649
Neuroscience. 2005;130(4):807-11
pubmed: 15652980
Brain. 2013 May;136(Pt 5):1592-608
pubmed: 23616586
Neuron. 2005 Jun 2;46(5):787-98
pubmed: 15924864
Neuron. 2010 Dec 22;68(6):1023-42
pubmed: 21172606
Brain. 2017 Feb;140(2):414-428
pubmed: 28007991
J Neurosci. 2005 Apr 20;25(16):4127-30
pubmed: 15843615
J Physiol. 2001 May 15;533(Pt 1):237-52
pubmed: 11351031
Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):E2635-44
pubmed: 22955882
Cell. 1998 Feb 20;92(4):573-85
pubmed: 9491897
J Neurosci. 2013 Jun 5;33(23):9743-51
pubmed: 23739971
Cell. 1999 Aug 20;98(4):437-51
pubmed: 10481909
J Neurosci. 2017 Apr 12;37(15):4007-4022
pubmed: 28209737
J Neurophysiol. 2007 Jan;97(1):837-48
pubmed: 17093123
Neuron. 2004 May 27;42(4):619-34
pubmed: 15157423
Nat Commun. 2016 Apr 22;7:11395
pubmed: 27102565
J Neurosci. 2014 May 14;34(20):6896-909
pubmed: 24828644
Sci Transl Med. 2018 Jun 27;10(447):
pubmed: 29950444
J Neurophysiol. 2005 Sep;94(3):2195-206
pubmed: 15958604
J Comp Neurol. 2006 Dec 1;499(4):645-61
pubmed: 17029265
Neuroscience. 1999;91(4):1389-99
pubmed: 10391445
eNeuro. 2017 Sep 22;4(5):
pubmed: 28966976
Eur J Neurosci. 2001 May;13(9):1733-44
pubmed: 11359525