von Willebrand Factor and Platelet Glycoprotein Ib: A Thromboinflammatory Axis in Stroke.
ADAMTS13
ischemic stroke
platelet glycoprotein Ibα
thromboinflammation
von Willebrand factor
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
31
08
2019
accepted:
25
11
2019
entrez:
11
1
2020
pubmed:
11
1
2020
medline:
11
11
2020
Statut:
epublish
Résumé
von Willebrand factor (VWF) and platelets are key mediators of normal hemostasis. At sites of vascular injury, VWF recruits platelets via binding to the platelet receptor glycoprotein Ibα (GPIbα). Over the past decades, it has become clear that many hemostatic factors, including VWF and platelets, are also involved in inflammatory processes, forming intriguing links between hemostasis, thrombosis, and inflammation. The so-called "thrombo-inflammatory" nature of the VWF-platelet axis becomes increasingly recognized in different cardiovascular pathologies, making it a potential therapeutic target to interfere with both thrombosis and inflammation. In this review, we discuss the current evidence for the thrombo-inflammatory activity of VWF with a focus on the VWF-GPIbα axis and discuss its implications in the setting of ischemic stroke.
Identifiants
pubmed: 31921147
doi: 10.3389/fimmu.2019.02884
pmc: PMC6928043
doi:
Substances chimiques
Platelet Glycoprotein GPIb-IX Complex
0
adhesion receptor
0
von Willebrand Factor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2884Subventions
Organisme : NINDS NIH HHS
ID : U24 NS107228
Pays : United States
Informations de copyright
Copyright © 2019 Denorme, Vanhoorelbeke and De Meyer.
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