Do All Opioid Drugs Share the Same Immunomodulatory Properties? A Review From Animal and Human Studies.
buprenophine
fentanyl
immunosuppression
methadone
morphine
oxycodone
tapentadol
tramadol
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
15
07
2019
accepted:
27
11
2019
entrez:
11
1
2020
pubmed:
11
1
2020
medline:
11
11
2020
Statut:
epublish
Résumé
Suppression of the immune system has been constantly reported in the last years as a classical side effect of opioid drugs. Most of the studies on the immunological properties of opioids refer to morphine. Although morphine remains the "reference molecule," other semisynthetic and synthetic opioids are frequently used in the clinical practice. The primary objective of this review is to analyze the available literature on the immunomodulating properties of opioid drugs different from morphine in preclinical models and in the human. A search strategy was conducted in PubMed, Embase, and the Cochrane databases using the terms "immunosuppression," "immune system," "opioids," "Natural killer cells," "cytokines," and "lymphocytes." The results achieved concerning the effects of fentanyl, methadone, oxycodone, buprenorphine, remifentanil, tramadol, and tapentadol on immune responses in animal studies, in healthy volunteers and in patients are reported. With some limitations due to the different methods used to measure immune system parameters, the large range of opioid doses and the relatively scarce number of participants in the available studies, we conclude that it is not correct to generalize immunosuppression as a common side effect of all opioid molecules.
Identifiants
pubmed: 31921173
doi: 10.3389/fimmu.2019.02914
pmc: PMC6920107
doi:
Substances chimiques
Analgesics, Opioid
0
Immunologic Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2914Informations de copyright
Copyright © 2019 Franchi, Moschetti, Amodeo and Sacerdote.
Références
Curr Pharm Des. 2012;18(37):6034-42
pubmed: 22747543
Inflammation. 2014 Oct;37(5):1654-60
pubmed: 24748477
Neuroimmunomodulation. 2004;11(4):255-60
pubmed: 15249732
Int Immunopharmacol. 2004 Nov;4(12):1525-30
pubmed: 15351321
PLoS One. 2015 Apr 01;10(4):e0122822
pubmed: 25830312
Curr Opin Crit Care. 2015 Aug;21(4):336-42
pubmed: 26103142
Anesthesiology. 2003 Jan;98(1):151-5
pubmed: 12502991
Brain Res Mol Brain Res. 1998 May;56(1-2):281-3
pubmed: 9602153
BMJ Support Palliat Care. 2014 Dec;4(4):357-67
pubmed: 24644198
Pain Pract. 2012 Apr;12(4):290-306
pubmed: 21797962
Clin Chim Acta. 2006 Jul 15;369(1):40-5
pubmed: 16487501
Int Immunopharmacol. 2018 Jan;54:344-353
pubmed: 29197801
J Perinatol. 2013 May;33(5):374-82
pubmed: 23047422
Expert Opin Drug Discov. 2017 Dec;12(12):1281-1291
pubmed: 28920461
Int J Med Sci. 2017 Aug 18;14(10):970-976
pubmed: 28924368
Am J Pathol. 2005 Nov;167(5):1333-40
pubmed: 16251417
Anesth Analg. 2002 Jan;94(1):94-9, table of contents
pubmed: 11772808
Pain. 2001 May;92(1-2):63-9
pubmed: 11323127
Int Immunopharmacol. 2001 Apr;1(4):713-9
pubmed: 11357883
Cell. 2017 Nov 16;171(5):1165-1175.e13
pubmed: 29149605
Br J Anaesth. 2019 Jun;122(6):e136-e145
pubmed: 31010646
J Int Med Res. 2008 Nov-Dec;36(6):1235-47
pubmed: 19094432
Can J Anaesth. 2005 Dec;52(10):1035-9
pubmed: 16326672
Brain Behav Immun. 2014 Nov;42:60-4
pubmed: 24975593
Drugs. 2005;65(13):1793-823
pubmed: 16114980
J Leukoc Biol. 2005 Dec;78(6):1185-91
pubmed: 16204646
Fundam Appl Toxicol. 1995 Feb;24(2):275-84
pubmed: 7737438
Adv Exp Med Biol. 1993;335:21-8
pubmed: 8237597
Expert Opin Drug Metab Toxicol. 2019 Jul;15(7):565-575
pubmed: 31211608
Am J Surg. 1994 Jan;167(1):174-9
pubmed: 8311130
Int J Immunopharmacol. 1995 Jun;17(6):535-43
pubmed: 7499032
J Clin Anesth. 2005 Dec;17(8):575-80
pubmed: 16427525
Br J Pharmacol. 1997 Jun;121(4):834-40
pubmed: 9208156
Toxicology. 1998 Aug 21;129(2-3):201-10
pubmed: 9772098
Br J Anaesth. 2003 Dec;91(6):805-9
pubmed: 14633749
CNS Drugs. 2011 May;25(5):359-70
pubmed: 21476608
J Neuroimmunol. 1998 Mar 15;83(1-2):4-18
pubmed: 9610668
Psychopharmacology (Berl). 2005 May;179(3):700-4
pubmed: 15806416
Br J Cancer. 2014 Aug 26;111(5):866-73
pubmed: 25025960
Mol Pain. 2016 Jun 17;12:
pubmed: 27317580
Data Brief. 2017 Dec 13;16:950-954
pubmed: 29322074
Eur J Pharmacol. 2004 Jun 28;494(2-3):251-62
pubmed: 15212982
Clin Microbiol Rev. 2003 Apr;16(2):209-19
pubmed: 12692094
Expert Opin Pharmacother. 2016 Dec;17(17):2307-2318
pubmed: 27734745
Int Immunopharmacol. 2001 May;1(5):821-31
pubmed: 11379038
Drugs. 2018 Aug;78(12):1211-1228
pubmed: 30051169
Front Pharmacol. 2018 Nov 29;9:1388
pubmed: 30555325
J Pain Symptom Manage. 2005 May;29(5 Suppl):S25-31
pubmed: 15907644
Br J Anaesth. 2013 Jul;111(1):80-8
pubmed: 23794649
Anesth Analg. 1996 Mar;82(3):492-7
pubmed: 8623949
Immunopharmacol Immunotoxicol. 2013 Apr;35(2):264-71
pubmed: 23480345
Acta Anaesthesiol Scand. 2000 Nov;44(10):1232-7
pubmed: 11065203
Clin Infect Dis. 2005 Oct 1;41(7):1027-34
pubmed: 16142670
Anesth Analg. 2017 Mar;124(3):986-995
pubmed: 27997452
Pain. 2004 Jul;110(1-2):385-92
pubmed: 15275790
J Neuroimmune Pharmacol. 2011 Dec;6(4):442-65
pubmed: 21789507
Pharmacol Rep. 2012;64(5):1200-15
pubmed: 23238476
Clin Immunol. 2003 Nov;109(2):179-87
pubmed: 14597216
Acta Anaesthesiol Scand. 2004 Jul;48(6):738-49
pubmed: 15196107
Curr Med Chem. 2020;27(9):1562-1575
pubmed: 31057099
Am J Ther. 2004 Sep-Oct;11(5):354-65
pubmed: 15356431
Psychiatry Res. 2015 Mar 30;226(1):230-4
pubmed: 25660662
Pain. 1997 Sep;72(3):325-30
pubmed: 9313273
J Leukoc Biol. 2018 Dec;104(6):1049-1059
pubmed: 29791013
Am J Hosp Palliat Care. 2013 Nov;30(7):712-6
pubmed: 23264664
Mol Pharmacol. 2019 Nov;96(5):542-549
pubmed: 31175184
J Neuroimmunol. 2013 Feb 15;255(1-2):39-44
pubmed: 23177720
Amino Acids. 2013 Jul;45(1):9-24
pubmed: 22170499
Res Publ Assoc Res Nerv Ment Dis. 1992;70:205-30
pubmed: 1346939
J Immunol. 2015 Apr 1;194(7):3246-58
pubmed: 25716997
Immunopharmacology. 2000 Jul 20;48(2):145-56
pubmed: 10936512
Medicine (Baltimore). 2017 Aug;96(31):e7519
pubmed: 28767570
Proc Natl Acad Sci U S A. 1979 Nov;76(11):5769-73
pubmed: 293681
Brain Behav Immun. 2007 Aug;21(6):767-74
pubmed: 17291715
J Neuroimmunol. 2013 Oct 15;263(1-2):35-42
pubmed: 23965172
Ochsner J. 2014 Summer;14(2):216-28
pubmed: 24940132
Br J Pharmacol. 2018 Jul;175(14):2726-2736
pubmed: 28593737
Trends Pharmacol Sci. 2013 Apr;34(4):206-14
pubmed: 23465410
Int J Immunopharmacol. 1999 Nov;21(11):727-34
pubmed: 10576618
Psychiatry Res. 2007 Jan 15;149(1-3):201-13
pubmed: 17129610
J Opioid Manag. 2008 Jan-Feb;4(1):27-33
pubmed: 18444445
J Med Toxicol. 2018 Dec;14(4):306-322
pubmed: 30377951
Int Immunopharmacol. 2019 Jan;66:330-335
pubmed: 30521961
J Neuroimmunol. 2004 Feb;147(1-2):28-32
pubmed: 14741423
Int J Immunopharmacol. 1999 Jul;21(7):445-54
pubmed: 10454018
J Neuroimmunol. 2002 Aug;129(1-2):18-24
pubmed: 12161016
J Pain Res. 2018 Jul 10;11:1297-1305
pubmed: 30022848
Brain Behav Immun. 2008 May;22(4):606-13
pubmed: 18294814
Eur J Anaesthesiol. 2010 Mar;27(3):233-40
pubmed: 19487949
J Anaesthesiol Clin Pharmacol. 2014 Apr;30(2):153-9
pubmed: 24803749
Hematol Oncol Clin North Am. 2018 Jun;32(3):405-415
pubmed: 29729777
Addiction. 2014 Dec;109(12):2053-9
pubmed: 25041346
J Anesth. 2013 Oct;27(5):676-83
pubmed: 23543346
Proc Natl Acad Sci U S A. 1998 May 26;95(11):6326-30
pubmed: 9600964
Anesth Analg. 2000 Jun;90(6):1411-4
pubmed: 10825330