A Proposed New Nomenclature for the Immunoglobulin Genes of
B cell
IGH
IGK
IGL
V genes
immunoglobulin
nomenclature
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
11
09
2019
accepted:
03
12
2019
entrez:
11
1
2020
pubmed:
11
1
2020
medline:
11
11
2020
Statut:
epublish
Résumé
Mammalian immunoglobulin (IG) genes are found in complex loci that contain hundreds of highly similar pseudogenes, functional genes and repetitive elements, which has made their investigation particularly challenging. High-throughput sequencing has provided new avenues for the investigation of these loci, and has recently been applied to study the IG genes of important inbred mouse strains, revealing unexpected differences between their IG loci. This demonstrated that the structural differences are of such magnitude that they call into question the merits of the current mouse IG gene nomenclatures. Three nomenclatures for the mouse IG heavy chain locus (
Identifiants
pubmed: 31921202
doi: 10.3389/fimmu.2019.02961
pmc: PMC6930147
doi:
Substances chimiques
Immunoglobulin Heavy Chains
0
Immunoglobulin kappa-Chains
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2961Informations de copyright
Copyright © 2019 Busse, Jackson, Watson and Collins.
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