Functional Impact of Human Genetic Variants of
Apoptosis
/ physiology
Cell Line
Cell Movement
/ physiology
Cell Proliferation
/ physiology
Collagen Type VIII
/ metabolism
Collagen Type XVIII
/ metabolism
Endostatins
/ metabolism
Endothelial Cells
/ metabolism
Endothelium
/ metabolism
Familial Primary Pulmonary Hypertension
/ metabolism
Human Genetics
/ methods
Humans
Lung
/ metabolism
Signal Transduction
/ physiology
apoptosis
endostatin
migration
proliferation
pulmonary arterial hypertension
Journal
American journal of respiratory cell and molecular biology
ISSN: 1535-4989
Titre abrégé: Am J Respir Cell Mol Biol
Pays: United States
ID NLM: 8917225
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
pubmed:
11
1
2020
medline:
18
7
2020
entrez:
11
1
2020
Statut:
ppublish
Résumé
Pulmonary arterial hypertension (PAH) is an incurable disease characterized by disordered and dysfunctional angiogenesis leading to small-vessel loss and an obliterative vasculopathy. The pathogenesis of PAH is not fully understood, but multiple studies have demonstrated links between elevated angiostatic factors, disease severity, and adverse clinical outcomes. ES (endostatin), one such circulating angiostatic peptide, is the cleavage product of the proteoglycan
Identifiants
pubmed: 31922883
doi: 10.1165/rcmb.2019-0056OC
pmc: PMC7110972
doi:
Substances chimiques
COL18A1 protein, human
0
Collagen Type VIII
0
Collagen Type XVIII
0
Endostatins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
524-534Subventions
Organisme : NHLBI NIH HHS
ID : K08 HL132055
Pays : United States
Commentaires et corrections
Type : CommentIn
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