Highly selective organ distribution and cellular uptake of inorganic-organic hybrid nanoparticles customized for the targeted delivery of glucocorticoids.

Animals Anti-Inflammatory Agents Fluorescent Dyes Glucocorticoids Macrophages Mice Nanoparticles
Drug delivery Endocytosis Glucocorticoids Inorganic-organic hybrid nanoparticles Macrophages

Journal

Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908

Informations de publication

Date de publication:
10 03 2020
Historique:
received: 16 09 2019
revised: 11 12 2019
accepted: 06 01 2020
pubmed: 11 1 2020
medline: 22 6 2021
entrez: 11 1 2020
Statut: ppublish

Résumé

We previously reported that inorganic-organic hybrid nanoparticles (IOH-NPs) containing the synthetic glucocorticoid (GC) betamethasone show efficient anti-inflammatory activity in mice. Here, we employed IOH-NPs with the chemical composition Gd

Identifiants

DOI: 10.1016/j.jconrel.2020.01.010 PMID: 31923534
pubmed: 31923534
pii: S0168-3659(20)30018-3
doi: 10.1016/j.jconrel.2020.01.010
pii:
doi:

Substances chimiques

Anti-Inflammatory Agents 0
Fluorescent Dyes 0
Glucocorticoids 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

360-370

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

Tina K Kaiser (TK)

Institute for Cellular and Molecular Immunology, University Medical Center Göttingen, 37073 Göttingen, Germany.

Mikhail Khorenko (M)

Institute of Inorganic Chemistry, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.

Amir Moussavi (A)

Functional Imaging Laboratory, German Primate Center, Leibniz Institute for Primate Research, 37077 Göttingen, Germany.

Michael Engelke (M)

Institute for Cellular and Molecular Immunology, University Medical Center Göttingen, 37073 Göttingen, Germany.

Susann Boretius (S)

Functional Imaging Laboratory, German Primate Center, Leibniz Institute for Primate Research, 37077 Göttingen, Germany.

Claus Feldmann (C)

Institute of Inorganic Chemistry, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.

Holger M Reichardt (HM)

Institute for Cellular and Molecular Immunology, University Medical Center Göttingen, 37073 Göttingen, Germany. Electronic address: hreichardt@med.uni-goettingen.de.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Highly selective organ distribution and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Highly selective organ distribution and...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Luminescents › Colorants fluorescents › Highly selective organ distribution and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Glucocorticoïdes › Highly selective organ distribution and...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Highly selective organ distribution and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Highly selective organ distribution and...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Highly selective organ distribution and...