Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4

Adoptive Transfer Animals Cell Line, Tumor Granzymes / immunology Humans Interferon-gamma / immunology Interleukin-2 / metabolism Mice Mice, Inbred C57BL Mice, Knockout Neoplasms / immunology Positive Regulatory Domain I-Binding Factor 1 / metabolism T-Box Domain Proteins / metabolism T-Lymphocytes, Regulatory / cytology Tumor Microenvironment / immunology
Blimp-1 CD4-mediated anti-tumor response IL-2 T-bet Treg depletion anti-CTLA-4 cytotoxic CD4(+) T cells regulatory T cells

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
14 01 2020
Historique:
received: 27 11 2018
revised: 30 09 2019
accepted: 12 12 2019
pubmed: 12 1 2020
medline: 6 2 2020
entrez: 12 1 2020
Statut: ppublish

Résumé

In addition to helper and regulatory potential, CD4

Identifiants

DOI: 10.1016/j.immuni.2019.12.007 PMID: 31924474 PMC: PMC7369640
pubmed: 31924474
pii: S1074-7613(19)30526-6
doi: 10.1016/j.immuni.2019.12.007
pmc: PMC7369640
pii:
doi:

Substances chimiques

IFNG protein, mouse 0
Interleukin-2 0
Prdm1 protein, mouse 0
T-Box Domain Proteins 0
T-box transcription factor TBX21 0
Interferon-gamma 82115-62-6
Positive Regulatory Domain I-Binding Factor 1 EC 2.1.1.-
Granzymes EC 3.4.21.-
Gzmb protein, mouse EC 3.4.21.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

151-166.e6

Subventions

Organisme : Worldwide Cancer Research
ID : 13-0316
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 12100
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C36463/A20764
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R001413/1
Pays : United Kingdom
Organisme : Department of Health
ID : 167097
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 536392/170773
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P011225/1
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C416/A18088
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : Medical Research Council
ID : MR/M003493/1
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C33499/A20265
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C36463/A22246
Pays : United Kingdom

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

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Auteurs

Anna Śledzińska (A)

Cancer Immunology Unit, UCL Cancer Institute, University College London, London WC1E 6DD, UK; Research Department of Haematology, University College London, Cancer Institute, London WC1E 6DD, UK.

Maria Vila de Mucha (M)

Cancer Immunology Unit, UCL Cancer Institute, University College London, London WC1E 6DD, UK; Regulatory Genomics Research Group, UCL Cancer Institute, University College London, London WC1E 6DD, UK.

Katharina Bergerhoff (K)

Cancer Immunology Unit, UCL Cancer Institute, University College London, London WC1E 6DD, UK; Research Department of Haematology, University College London, Cancer Institute, London WC1E 6DD, UK.

Alastair Hotblack (A)

Research Department of Haematology, University College London, Cancer Institute, London WC1E 6DD, UK.

Dafne Franz Demane (DF)

Cancer Immunology Unit, UCL Cancer Institute, University College London, London WC1E 6DD, UK; Research Department of Haematology, University College London, Cancer Institute, London WC1E 6DD, UK.

Ehsan Ghorani (E)

Cancer Immunology Unit, UCL Cancer Institute, University College London, London WC1E 6DD, UK; Research Department of Haematology, University College London, Cancer Institute, London WC1E 6DD, UK.

Ayse U Akarca (AU)

Department of Cellular Pathology, University College London Hospital, London NW1 2BU, UK.

Maria A V Marzolini (MAV)

Cancer Immunology Unit, UCL Cancer Institute, University College London, London WC1E 6DD, UK; Research Department of Haematology, University College London, Cancer Institute, London WC1E 6DD, UK.

Isabelle Solomon (I)

Cancer Immunology Unit, UCL Cancer Institute, University College London, London WC1E 6DD, UK; Research Department of Haematology, University College London, Cancer Institute, London WC1E 6DD, UK.

Frederick Arce Vargas (FA)

Cancer Immunology Unit, UCL Cancer Institute, University College London, London WC1E 6DD, UK; Research Department of Haematology, University College London, Cancer Institute, London WC1E 6DD, UK.

Martin Pule (M)

Research Department of Haematology, University College London, Cancer Institute, London WC1E 6DD, UK.

Masahiro Ono (M)

Faculty of Natural Sciences, Department of Life Sciences, Imperial College London, London SW7 2BB, UK.

Benedict Seddon (B)

Institute of Immunity and Transplantation, Department of Immunology, Royal Free Hospital, London NW3 2PF, UK.

George Kassiotis (G)

Retroviral Immunology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

Charlotte E Ariyan (CE)

Memorial Sloan Kettering Center, 1275 York Avenue, New York, NY 10065, USA.

Thomas Korn (T)

Department of Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany.

Teresa Marafioti (T)

Department of Cellular Pathology, University College London Hospital, London NW1 2BU, UK.

Graham M Lord (GM)

Faculty of Biology, Medicine and Health, University of Manchester, 46 Grafton Street, Manchester M13 9NT, UK.

Hans Stauss (H)

Institute of Immunity and Transplantation, Department of Immunology, Royal Free Hospital, London NW3 2PF, UK.

Richard G Jenner (RG)

Regulatory Genomics Research Group, UCL Cancer Institute, University College London, London WC1E 6DD, UK.

Karl S Peggs (KS)

Cancer Immunology Unit, UCL Cancer Institute, University College London, London WC1E 6DD, UK; Research Department of Haematology, University College London, Cancer Institute, London WC1E 6DD, UK. Electronic address: k.peggs@ucl.ac.uk.

Sergio A Quezada (SA)

Cancer Immunology Unit, UCL Cancer Institute, University College London, London WC1E 6DD, UK; Research Department of Haematology, University College London, Cancer Institute, London WC1E 6DD, UK. Electronic address: s.quezada@ucl.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunisation passive › Transfert adoptif › Regulatory T Cells Restrain Interleukin-2- and...
questionsmedicales.fr › Eucaryotes › Animaux › Regulatory T Cells Restrain Interleukin-2- and...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Regulatory T Cells Restrain Interleukin-2- and...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Serine endopeptidases › Granzymes › Regulatory T Cells Restrain Interleukin-2- and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Regulatory T Cells Restrain Interleukin-2- and...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Facteurs d'activation des macrophages › Interféron gamma › Regulatory T Cells Restrain Interleukin-2- and...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Interleukine-2 › Regulatory T Cells Restrain Interleukin-2- and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Regulatory T Cells Restrain Interleukin-2- and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Regulatory T Cells Restrain Interleukin-2- and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Regulatory T Cells Restrain Interleukin-2- and...
questionsmedicales.fr › Tumeurs › Regulatory T Cells Restrain Interleukin-2- and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Facteur-1 liant le domaine de régulation positive I › Regulatory T Cells Restrain Interleukin-2- and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines à domaine boîte-T › Regulatory T Cells Restrain Interleukin-2- and...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Regulatory T Cells Restrain Interleukin-2- and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Regulatory T Cells Restrain Interleukin-2- and...