Gallic acid prevents 1, 2-Dimethylhydrazine induced colon inflammation, toxicity, mucin depletion, and goblet cell disintegration.
1,2-Dimethylhydrazine
/ toxicity
Animals
Anti-Inflammatory Agents
/ toxicity
Antioxidants
/ metabolism
Apoptosis
/ drug effects
Cell Proliferation
/ drug effects
Dose-Response Relationship, Drug
Female
Gallic Acid
/ pharmacology
Glutathione
/ metabolism
Goblet Cells
/ drug effects
Inflammation
Mucins
/ metabolism
Oxidative Stress
/ drug effects
Rats
Rats, Wistar
1,2-Dimethylhydrazine
apoptosis
colon toxicity
gallic acid
mucin
oxidative stress
Journal
Environmental toxicology
ISSN: 1522-7278
Titre abrégé: Environ Toxicol
Pays: United States
ID NLM: 100885357
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
19
10
2019
revised:
30
11
2019
accepted:
27
12
2019
pubmed:
12
1
2020
medline:
17
6
2020
entrez:
12
1
2020
Statut:
ppublish
Résumé
1,2-Dimethylhydrazine (DMH), an environmental toxicant specifically targets the colon. The present study was aimed to evaluate the efficacy of gallic acid (GA) against colon toxicity induced by DMH in Wistar rats. GA, a phenolic acid has numerous beneficial properties, which include antiviral, antifungal and antioxidant properties which help cells to overcome oxidative stress and balance the redox homeostasis. GA was administered orally at two doses (25 and 50 mg/kg body weight) once daily for 14 days and a single dose (40 mg/kg body weight) of DMH was administered subcutaneously on 14th day. Animals were sacrificed on the 15th day and we could find that GA at both the doses significantly ameliorates DMH-induced increased toxicity markers and also substantially increases the glutathione content level and activities of detoxifying enzymes. It also ameliorates the expression of proliferation, inflammation, apoptosis, goblet cell disintegration, and mucin depletion in the colon that was elevated upon administration of DMH. Histological alterations provide further confirmation of the protective role of GA against DMH-induced colon toxicity. The results of this study clearly indicate supplementation of GA is beneficial in ameliorating DMH-induced oxidative stress, inflammation, proliferation, apoptosis, mucin depletion, and goblet cell disintegration in colon of Wistar rats.
Substances chimiques
Anti-Inflammatory Agents
0
Antioxidants
0
Mucins
0
Gallic Acid
632XD903SP
Glutathione
GAN16C9B8O
1,2-Dimethylhydrazine
IX068S9745
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
652-664Informations de copyright
© 2020 Wiley Periodicals, Inc.
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