Humanized mice as preclinical models for myeloid malignancies.
Cytokine humanization
Humanized mice
Immunodeficient mouse models
Myeloid malignancy
Pre-clinical studies
Xenotransplantation
Journal
Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
15
11
2019
accepted:
07
01
2020
pubmed:
14
1
2020
medline:
25
8
2020
entrez:
14
1
2020
Statut:
ppublish
Résumé
Humanized mice have proven to be invaluable for human hematological translational research since they offer essential tools to dissect disease biology and to bridge the gap between pre-clinical testing of novel therapeutics and their clinical applications. Many efforts have been placed to advance and optimize humanized mice to support the engraftment, differentiation, and maintenance of hematopoietic stem cells (HSCs) and the human hematological system in order to broaden the scope of applications of such models. This review covers the background of humanized mice, how they are used as platforms to model myeloid malignancies, and the various current and potential approaches to further enhance their utilization in biomedical research.
Identifiants
pubmed: 31926939
pii: S0006-2952(20)30004-6
doi: 10.1016/j.bcp.2020.113794
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
113794Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.