Immunophenotypic analysis of cerebrospinal fluid reveals concurrent development of ATL in the CNS of a HAM/TSP patient.
Adult T-cell leukemia/lymphoma (ATL)
Central nervous system involvement
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Multi-color flow cytometry
Journal
International journal of hematology
ISSN: 1865-3774
Titre abrégé: Int J Hematol
Pays: Japan
ID NLM: 9111627
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
09
09
2019
accepted:
26
12
2019
revised:
26
12
2019
pubmed:
14
1
2020
medline:
30
9
2020
entrez:
14
1
2020
Statut:
ppublish
Résumé
Both adult T-cell leukemia/lymphoma (ATL) and human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) can be induced by HTLV-1, but concurrent development has been rarely reported. We present the case of a 55-year-old female who developed cranial nerve symptoms after a 20-year history of HAM/TSP. Although multiple white matter lesions were observed on brain magnetic resonance imaging, no abnormalities were seen on a systemic computed tomography scan. Quantitative flow-cytometric analysis of cell populations in the cerebrospinal fluid (CSF) revealed that most of the infiltrating cells were not inflammatory cells, but HTLV-1-infected CD4
Identifiants
pubmed: 31930455
doi: 10.1007/s12185-019-02815-7
pii: 10.1007/s12185-019-02815-7
pmc: PMC7222977
doi:
Substances chimiques
Antigens, CD7
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
891-896Références
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