Characterisation of the binding of dihydro-alpha-lipoic acid to fibrinogen and the effects on fibrinogen oxidation and fibrin formation.

Antioxidants / pharmacology Fibrin / metabolism Fibrinogen / chemistry Molecular Docking Simulation Oxidation-Reduction Protein Structure, Secondary Spectrometry, Fluorescence Spectrophotometry, Ultraviolet Spectroscopy, Fourier Transform Infrared Thioctic Acid / metabolism
Molecular modelling Protein function Protein interaction

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
15 Mar 2020
Historique:
received: 05 11 2019
revised: 08 01 2020
accepted: 09 01 2020
pubmed: 14 1 2020
medline: 28 11 2020
entrez: 14 1 2020
Statut: ppublish

Résumé

A reduced form of the alpha-lipoic acid, dihydro-alpha-lipoic acid (DHLA) is a potent, naturally occurring antioxidant which can be consumed as food constituent or as supplement at doses up to 600 mg/day. DHLA has inhibitory effect on coagulation as it can reduce concentrations of some coagulation factors. In this study, a direct interaction between DHLA and fibrinogen, the main protein in coagulation, is described. Binding constant for DHLA/fibrinogen complex is of moderate strength (10

Identifiants

DOI: 10.1016/j.ijbiomac.2020.01.098 PMID: 31931063
pubmed: 31931063
pii: S0141-8130(19)39010-5
doi: 10.1016/j.ijbiomac.2020.01.098
pii:
doi:

Substances chimiques

Antioxidants 0
Thioctic Acid 73Y7P0K73Y
Fibrin 9001-31-4
Fibrinogen 9001-32-5

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

319-325

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

Nikola Gligorijević (N)

Institute for the Application of Nuclear Energy (INEP), Department for Metabolism, University of Belgrade, Banatska 31b, 11000 Belgrade, Serbia. Electronic address: nikolag@inep.co.rs.

Vladimir Šukalović (V)

Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Njegoševa 12, 11000 Belgrade, Serbia.

Ana Penezić (A)

Institute for the Application of Nuclear Energy (INEP), Department for Metabolism, University of Belgrade, Banatska 31b, 11000 Belgrade, Serbia.

Olgica Nedić (O)

Institute for the Application of Nuclear Energy (INEP), Department for Metabolism, University of Belgrade, Banatska 31b, 11000 Belgrade, Serbia.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Characterisation of the binding of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Fibrine › Characterisation of the binding of...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Fibrinogène › Characterisation of the binding of...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Characterisation of the binding of...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Characterisation of the binding of...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › Characterisation of the binding of...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectrométrie de fluorescence › Characterisation of the binding of...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectrophotométrie › Spectrophotométrie UV › Characterisation of the binding of...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectrophotométrie › Spectrophotométrie IR › Spectroscopie infrarouge à transformée de Fourier › Characterisation of the binding of...
questionsmedicales.fr › Lipides › Acides gras › Acide lipoïque › Characterisation of the binding of...