The investigation of synergistic activity of protamine with conventional antimicrobial agents against oral bacteria.
3-methyl-4-isopropylphenol
Antimicrobial peptide
Protamine
Streptococcus gordonii
Streptococcus mutans
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
12 03 2020
12 03 2020
Historique:
received:
07
12
2019
accepted:
02
01
2020
pubmed:
15
1
2020
medline:
9
9
2020
entrez:
15
1
2020
Statut:
ppublish
Résumé
In this study, we applied protamine, which is an antimicrobial peptide, to oral healthcare in combination with conventional antimicrobial agents. First, we explored the antimicrobial activity of protamine, with or without other antimicrobial agents, against Streptococcus mutans (S. mutans). Co-treatment with protamine and 3-methyl-4-isopropylphenol (IPMP) decreased the viability of S. mutans synergistically within 10 min. Interestingly, sodium fluoride (NaF) did not exhibit synergistic activity with protamine. Next, S. mutans and Streptococcus gordonii (S. gordonii) were co-treated with protamine and IPMP for 5 min to simulate tooth brushing. As a result, this co-treatment killed S. mutans faster than S. gordonii. Therefore, co-treatment with protamine and IPMP could be incorporated into oral healthcare products to prevent dental caries.
Identifiants
pubmed: 31932035
pii: S0006-291X(20)30009-7
doi: 10.1016/j.bbrc.2020.01.002
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Protamines
0
Sodium Fluoride
8ZYQ1474W7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
561-566Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no conflicts of interest.