Nucleus-specific linker histones Hho1 and Mlh1 form distinct protein interactions during growth, starvation and development in Tetrahymena thermophila.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
13 01 2020
Historique:
received: 19 07 2019
accepted: 14 11 2019
entrez: 15 1 2020
pubmed: 15 1 2020
medline: 13 11 2020
Statut: epublish

Résumé

Chromatin organization influences most aspects of gene expression regulation. The linker histone H1, along with the core histones, is a key component of eukaryotic chromatin. Despite its critical roles in chromatin structure and function and gene regulation, studies regarding the H1 protein-protein interaction networks, particularly outside of Opisthokonts, are limited. The nuclear dimorphic ciliate protozoan Tetrahymena thermophila encodes two distinct nucleus-specific linker histones, macronuclear Hho1 and micronuclear Mlh1. We used a comparative proteomics approach to identify the Hho1 and Mlh1 protein-protein interaction networks in Tetrahymena during growth, starvation, and sexual development. Affinity purification followed by mass spectrometry analysis of the Hho1 and Mlh1 proteins revealed a non-overlapping set of co-purifying proteins suggesting that Tetrahymena nucleus-specific linker histones are subject to distinct regulatory pathways. Furthermore, we found that linker histones interact with distinct proteins under the different stages of the Tetrahymena life cycle. Hho1 and Mlh1 co-purified with several Tetrahymena-specific as well as conserved interacting partners involved in chromatin structure and function and other important cellular pathways. Our results suggest that nucleus-specific linker histones might be subject to nucleus-specific regulatory pathways and are dynamically regulated under different stages of the Tetrahymena life cycle.

Identifiants

pubmed: 31932604
doi: 10.1038/s41598-019-56867-0
pii: 10.1038/s41598-019-56867-0
pmc: PMC6957481
doi:

Substances chimiques

Chromatin 0
High Mobility Group Proteins 0
Histones 0
Proteome 0
Protozoan Proteins 0
MutL Protein Homolog 1 EC 3.6.1.3

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

168

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Auteurs

Syed Nabeel-Shah (S)

Department of Chemistry and Biology, Ryerson University, 350 Victoria St., Toronto, M5B 2K3, Canada.
Donnelly Centre, University of Toronto, Toronto, M5S 3E1, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, M5S 1A8, Canada.

Kanwal Ashraf (K)

Department of Biology, York University, 4700 Keele St., Toronto, M3J 1P3, Canada.

Alejandro Saettone (A)

Department of Chemistry and Biology, Ryerson University, 350 Victoria St., Toronto, M5B 2K3, Canada.

Jyoti Garg (J)

Department of Biology, York University, 4700 Keele St., Toronto, M3J 1P3, Canada.

Joanna Derynck (J)

Department of Chemistry and Biology, Ryerson University, 350 Victoria St., Toronto, M5B 2K3, Canada.

Jean-Philippe Lambert (JP)

Department of Molecular Medicine and Cancer Research Centre, Université Laval, Quebec, Canada.
CHU de Québec Research Center, CHUL, 2705 Laurier Boulevard, Quebec, G1V 4G2, Canada.

Ronald E Pearlman (RE)

Department of Biology, York University, 4700 Keele St., Toronto, M3J 1P3, Canada. ronp@yorku.ca.

Jeffrey Fillingham (J)

Department of Chemistry and Biology, Ryerson University, 350 Victoria St., Toronto, M5B 2K3, Canada. jeffrey.fillingham@ryerson.ca.

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