[Henoch-Shonlein purpura in adults in South Tunisia: a series of 14 cases].
Purpura rhumatoïde de l’adulte dans le sud tunisien: une série de 14 cas.
Henoch-Shonlein purpura
adult
nephropathy
Journal
The Pan African medical journal
ISSN: 1937-8688
Titre abrégé: Pan Afr Med J
Pays: Uganda
ID NLM: 101517926
Informations de publication
Date de publication:
2019
2019
Historique:
received:
27
10
2018
accepted:
26
07
2019
entrez:
15
1
2020
pubmed:
15
1
2020
medline:
22
1
2020
Statut:
epublish
Résumé
Henoch-Schonlein purpura (HSP) is a small-vessel vasculitis secondary to IgA deposits. We conducted a retrospective study of 14 cases of HSP in adults based on EULAR/PRINTO/PRES classification criteria for HSP over a period of 18 years (1996 to 2014) in Department of Internal Medicine at the Hedi Chaker University Hospital, Sfax, South Tunisia. The purpose of our study was to highlight the epidemiological, clinical, therapeutic and evolutionary features of HSP in our adult patients. The average age of patients was 33 years (ranging from 17-64 years) with male predominance (sex ratio of 1.8). Vascular purpura with petechiae was constant. Articular manifestations (arthralgia and/or arthritis) were reported in 9 patients (64.2%). Gastrointestinal involvement was reported in 13 patients (92.8%). Renal failure was found in 11 patients (78.5%) revealed by nephrotic proteinuria in 7 cases, microscopic haematuria in 9 cases, high blood pressure in 4 cases and renal impairment in 1 case. The most common histological type was diffuse proliferative endocapillary glomerulonephritis (36.3%). High dose corticotherapy was initiated in 7 patients with proliferative renal impairment, bolus of Solu-Medrol in 4 cases, associated with cyclophosphamide in one case. Two patients with severe gastrointestinal involvement received corticotherapy. After a mean follow-up period of 18.5 months (4-36 months), outcome was favorable in all cases without relapse and chronic renal failure was reported only in one case.
Identifiants
pubmed: 31934249
doi: 10.11604/pamj.2019.34.107.17274
pii: PAMJ-34-107
pmc: PMC6945384
doi:
Substances chimiques
Glucocorticoids
0
Immunosuppressive Agents
0
Cyclophosphamide
8N3DW7272P
Types de publication
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
107Informations de copyright
© Hanen Loukil et al.
Déclaration de conflit d'intérêts
Les auteurs ne déclarent aucun conflit d’intérêts.
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