Fructose and hepatic insulin resistance.
NAFLD
Sugar
fructose
insulin resistance
obesity
sugar-sweetened beverages
Journal
Critical reviews in clinical laboratory sciences
ISSN: 1549-781X
Titre abrégé: Crit Rev Clin Lab Sci
Pays: England
ID NLM: 8914816
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
pubmed:
15
1
2020
medline:
5
6
2021
entrez:
15
1
2020
Statut:
ppublish
Résumé
Excessive caloric intake in a form of high-fat diet (HFD) was long thought to be the major risk factor for development of obesity and its complications, such as fatty liver disease and insulin resistance. Recently, there has been a paradigm shift and more attention is attributed to the effects of sugar-sweetened beverages (SSBs) as one of the culprits of the obesity epidemic. In this review, we present the data invoking fructose intake with development of hepatic insulin resistance in human studies and discuss the pathways by which fructose impairs hepatic insulin action in experimental animal models. First, we described well-characterized pathways by which fructose metabolism indirectly leads to hepatic insulin resistance. These include unequivocal effects of fructose to promote de novo lipogenesis (DNL), impair fatty acid oxidation (FAO), induce endoplasmic reticulum (ER) stress and trigger hepatic inflammation. Additionally, we entertained the hypothesis that fructose can directly impede insulin signaling in the liver. This appears to be mediated by reduced insulin receptor and insulin receptor substrate 2 (IRS2) expression, increased protein-tyrosine phosphatase 1B (PTP1b) activity, whereas knockdown of ketohexokinase (KHK), the rate-limiting enzyme of fructose metabolism, increased insulin sensitivity. In summary, dietary fructose intake strongly promotes hepatic insulin resistance
Identifiants
pubmed: 31935149
doi: 10.1080/10408363.2019.1711360
pmc: PMC7774304
mid: NIHMS1550215
doi:
Substances chimiques
Fructose
30237-26-4
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
308-322Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK040561
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK048520
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM127211
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK121967
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK033201
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK031036
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK099222
Pays : United States
Organisme : NIDDK NIH HHS
ID : R37 DK031036
Pays : United States
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