Samir Softic

Affiliations

Division of Gastroenterology, Hepatology and Nutrition.
Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Boston, MA.

Publications (34)

Risk-factors Associated With Poor Outcomes in VEO-IBD Secondary to XIAP Deficiency: A Case Report and Literature Review.

Journal of pediatric gastroenterology and nutrition

Avec: Asama Lekbua , Jodie Ouahed , Amy E O'Connell , Stacy A Kahn , Jeffrey D Goldsmith , Toshihiko Imamura , Christine N Duncan , Judith R Kelsen , Elizabeth Worthey , Scott B Snapper , Samir Softic

Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation.

Molecular cell

Avec: GuoXiao Wang , Jesse G Meyer , Weikang Cai , Samir Softic , Mengyao Ella Li , Eric Verdin , Christopher Newgard , Birgit Schilling , C Ronald Kahn

Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD.

bioRxiv : the preprint server for biology

Avec: Se-Hyung Park , Robert N Helsley , Taghreed Fadhul , Jennifer L S Willoughby , Leila Noetzli , Ho-Chou Tu , Marie H Solheim , Shiho Fujisaka , Hui Pan , Jonathan M Dreyfuss , Joanna Bons , Jacob Rose , Christina D King , Birgit Schilling , Aldons J Lusis , Calvin Pan , Manoj Gupta , Rohit N Kulkarni , Kevin Fitzgerald , Philip A Kern , Senad Divanovic , C Ronald Kahn , Samir Softic

Fructose and hepatic insulin resistance.

Critical reviews in clinical laboratory sciences

Avec: Samir Softic , Kimber L Stanhope , Jeremie Boucher , Senad Divanovic , Miguel A Lanaspa , Richard J Johnson , C Ronald Kahn

Stratification by obesity class, rather than age, can identify a higher percent of children at risk for non-alcoholic fatty liver disease and metabolic dysfunction.

Pediatric obesity

Avec: Aurelia Radulescu , Adam J Dugan , Mary Killian , Suzanna L Attia , Marialena Mouzaki , George J Fuchs , Rohit Kohli , Henrietta Bada , Philip A Kern , Samir Softic

Differential roles of FOXO transcription factors on insulin action in brown and white adipose tissue.

The Journal of clinical investigation

Avec: Erica P Homan , Bruna B Brandão , Samir Softic , Abdelfattah El Ouaamari , Brian T O'Neill , Rohit N Kulkarni , Jason K Kim , C Ronald Kahn

Non-hematopoietic IL-4Rα expression contributes to fructose-driven obesity and metabolic sequelae.

International journal of obesity (2005)

Avec: Michelle S M A Damen , Traci E Stankiewicz , Se-Hyung Park , Robert N Helsley , Calvin C Chan , Maria E Moreno-Fernandez , Jessica R Doll , Sara Szabo , De'Broski R Herbert , Samir Softic , Senad Divanovic

Hepatic kinome atlas: An in-depth identification of kinase pathways in liver fibrosis of humans and rodents.

Hepatology (Baltimore, Md.)

Avec: Justin F Creeden , Zachary A Kipp , Mei Xu , Robert M Flight , Hunter N B Moseley , Genesee J Martinez , Wang-Hsin Lee , Khaled Alganem , Ali S Imami , Megan R McMullen , Sanjoy Roychowdhury , Atta M Nawabi , Jennifer A Hipp , Samir Softic , Steven A Weinman , Robert McCullumsmith , Laura E Nagy , Terry D Hinds

Dietary Counseling Aimed at Reducing Sugar Intake Yields the Greatest Improvement in Management of Weight and Metabolic Dysfunction in Children with Obesity.

Nutrients

Avec: Aurelia Radulescu , Mary Killian , Qiwen Kang , Qingcong Yuan , Samir Softic

Fructose impairs fat oxidation: Implications for the mechanism of western diet-induced NAFLD.

The Journal of nutritional biochemistry

Avec: Mustafa Kutlu Inci , Se-Hyung Park , Robert N Helsley , Suzanna L Attia , Samir Softic

Fructose Metabolism and Metabolic Dysfunction in Adolescents and Young Adults.

Nutrients

Avec: Samir Softic , Miguel A Lanaspa , Brian DeBosch

Author Correction: Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin.

Nature biomedical engineering

Avec: Mari Saif , Wilhelmus J Kwanten , Jessica A Carr , Ivy X Chen , Jessica M Posada , Amitabh Srivastava , Juanye Zhang , Yi Zheng , Matthias Pinter , Sampurna Chatterjee , Samir Softic , C Ronald Kahn , Klaus van Leyen , Oliver T Bruns , Rakesh K Jain , Moungi G Bawendi

Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism.

Nature communications

Avec: Mengyao Ella Li , Hans P M M Lauritzen , Brian T O'Neill , Chih-Hao Wang , Weikang Cai , Bruna B Brandao , Masaji Sakaguchi , Rongya Tao , Michael F Hirshman , Samir Softic , C Ronald Kahn

Muscle-Specific Insulin Receptor Overexpression Protects Mice From Diet-Induced Glucose Intolerance but Leads to Postreceptor Insulin Resistance.

Diabetes

Avec: Guoxiao Wang , Yingying Yu , Weikang Cai , Thiago M Batista , Sujin Suk , Hye Lim Noh , Michael Hirshman , Pasquale Nigro , Mengyao Ella Li , Samir Softic , Laurie Goodyear , Jason K Kim , C Ronald Kahn

A luminescence-based protocol for assessing fructose metabolism via quantification of ketohexokinase enzymatic activity in mouse or human hepatocytes.

STAR protocols

Avec: Se-Hyung Park , Robert N Helsley , Leila Noetzli , Ho-Chou Tu , Kristina Wallenius , Gavin O'Mahony , Jeremie Boucher , Jianming Liu , Samir Softic

De Novo Crohn's Disease Diagnosed in the Setting of Acute SARS-Cov-2 Infection Requiring Escalation of Infliximab Therapy Guided by Personalized Pharmacokinetics.

Journal of pediatrics, perinatology and child health

Avec: Martin Varea Romo , Kishor Acharya , Nathan R Shelman , Phillip Minar , Lee A Denson , Samir Softic

Ketohexokinase-C regulates global protein acetylation to decrease carnitine palmitoyltransferase 1a-mediated fatty acid oxidation.

Journal of hepatology

Avec: Robert N Helsley , Se-Hyung Park , Hemendra J Vekaria , Patrick G Sullivan , Lindsey R Conroy , Ramon C Sun , María Del Mar Romero , Laura Herrero , Joanna Bons , Christina D King , Jacob Rose , Jesse G Meyer , Birgit Schilling , C Ronald Kahn , Samir Softic

Hepatocyte Stress Increases Expression of Yes-Associated Protein and Transcriptional Coactivator With PDZ-Binding Motif in Hepatocytes to Promote Parenchymal Inflammation and Fibrosis.

Hepatology (Baltimore, Md.)

Avec: Meghan Mooring , Brendan H Fowl , Shelly Z C Lum , Ye Liu , Kangning Yao , Samir Softic , Rory Kirchner , Aaron Bernstein , Aatur D Singhi , Daniel G Jay , C Ronald Kahn , Fernando D Camargo , Dean Yimlamai

Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins.

Cell metabolism

Avec: Samir Softic , Jesse G Meyer , Guo-Xiao Wang , Manoj K Gupta , Thiago M Batista , Hans P M M Lauritzen , Shiho Fujisaka , Dolors Serra , Laura Herrero , Jennifer Willoughby , Kevin Fitzgerald , Olga Ilkayeva , Christopher B Newgard , Bradford W Gibson , Birgit Schilling , David E Cohen , C Ronald Kahn

Peripheral Insulin Regulates a Broad Network of Gene Expression in Hypothalamus, Hippocampus, and Nucleus Accumbens.

Diabetes

Avec: Weikang Cai , Xuemei Zhang , Thiago M Batista , Rubén García-Martín , Samir Softic , Guoxiao Wang , Alfred K Ramirez , Masahiro Konishi , Brian T O'Neill , Jong Hun Kim , Jason K Kim , C Ronald Kahn

Loss of carnitine palmitoyltransferase 1a reduces docosahexaenoic acid-containing phospholipids and drives sexually dimorphic liver disease in mice.

Molecular metabolism

Avec: Mikala M Zelows , Corissa Cady , Nikitha Dharanipragada , Anna E Mead , Zachary A Kipp , Evelyn A Bates , Venkateshwari Varadharajan , Rakhee Banerjee , Se-Hyung Park , Nathan R Shelman , Harrison A Clarke , Tara R Hawkinson , Terrymar Medina , Ramon C Sun , Todd A Lydic , Terry D Hinds , J Mark Brown , Samir Softic , Gregory A Graf , Robert N Helsley

Direct cost variance analysis of peroral endoscopic myotomy

World journal of gastrointestinal endoscopy

Avec: Syedreza Ali Haider , Gregory S Bills , C Prakash Gyawali , Passisd Laoveeravat , Jordan Miller , Samir Softic , Mihir S Wagh , Moamen Gabr

The bidirectional immune crosstalk in metabolic dysfunction-associated steatotic liver disease.

Cell metabolism

Avec: Keisuke Sawada , Hak Chung , Samir Softic , Maria E Moreno-Fernandez , Senad Divanovic

Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin.

Nature biomedical engineering

Evolving Role for Pharmacotherapy in NAFLD/NASH.

Clinical and translational science

Avec: Suzanna L Attia , Samir Softic , Marialena Mouzaki

Tissue-Specific Fructose Metabolism in Obesity and Diabetes.

Current diabetes reports

Avec: Robert N Helsley , Francois Moreau , Manoj K Gupta , Aurelia Radulescu , Brian DeBosch , Samir Softic

Leptin Receptor Signaling Regulates Protein Synthesis Pathways and Neuronal Differentiation in Pluripotent Stem Cells.

Stem cell reports

Avec: Manoj K Gupta , Heidrun Vethe , Samir Softic , Tata Nageswara Rao , Vilas Wagh , Jun Shirakawa , Harald Barsnes , Marc Vaudel , Tomozumi Takatani , Sevim Kahraman , Masaji Sakaguchi , Rachael Martinez , Jiang Hu , Yngvild Bjørlykke , Helge Raeder , Rohit N Kulkarni

Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice.

Molecular metabolism

Avec: Yoshiyuki Watanabe , Shiho Fujisaka , Yoshitomo Morinaga , Shiro Watanabe , Allah Nawaz , Hideki Hatta , Tomonobu Kado , Ayumi Nishimura , Muhammad Bilal , Muhammad Rahil Aslam , Keiko Honda , Yoshimi Nakagawa , Samir Softic , Kenichi Hirabayashi , Takashi Nakagawa , Yoshinori Nagai , Kazuyuki Tobe

Liver-specific FGFR4 knockdown in mice on an HFD increases bile acid synthesis and improves hepatic steatosis.

Journal of lipid research

Avec: Francois Moreau , Bruna Brasil Brunao , Xiang-Yu Liu , Frederic Tremblay , Kevin Fitzgerald , Julian Avila-Pacheco , Clary Clish , Ronald C Kahn , Samir Softic

Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD.

Metabolism: clinical and experimental

Loss of Carnitine Palmitoyltransferase 1a Reduces Docosahexaenoic Acid-Containing Phospholipids and Drives Sexually Dimorphic Liver Disease in Mice.

bioRxiv : the preprint server for biology

The combined pioglitazone and topiramate therapy for management of pediatric patients with severe MASLD.

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association

Avec: Callen Conroy , Aurelia Radulescu , Suzanna L Attia , Nathan Shelman , James T Lee , Roberto Galuppo Monticelli , Sara Hall , Rohit Kohli , Samir Softic

Growth Hormone Treatment Normalized Liver Enzymes in an Adolescent with Obesity and Short Statute.

Annals of pediatrics

Avec: Mensur Zvekic , Maddie Herbert , Alba Morales , Samir Softic

Knockdown of Ketohexokinase Versus Inhibition of Its Kinase Activity Exert Divergent Effects on Fructose Metabolism.

JCI insight

Avec: Se-Hyung Park , Taghreed Fadhul , Lindsey R Conroy , Harrison A Clarke , Ramon C Sun , Kristina Wallenius , Jeremie Boucher , Gavin O'Mahony , Alessandro Boianelli , Marie Persson , Sunhee Jung , Cholsoon Jang , Analia S Loria , Genesee J Martinez , Zachary A Kipp , Evelyn A Bates , Terry D Hinds , Senad Divanovic , Samir Softic

Réseau de co-auteurs

C Ronald Kahn 13 collaborations

Se-Hyung Park 9 collaborations

Robert N Helsley 9 collaborations

Senad Divanovic 6 collaborations

Birgit Schilling 5 collaborations

Weikang Cai 4 collaborations

Shiho Fujisaka 4 collaborations

Rohit N Kulkarni 4 collaborations

Kevin Fitzgerald 4 collaborations

Aurelia Radulescu 4 collaborations

Suzanna L Attia 4 collaborations

Zachary A Kipp 4 collaborations

Terry D Hinds 4 collaborations

Ramon C Sun 4 collaborations

Jesse G Meyer 3 collaborations

Mengyao Ella Li 3 collaborations

Taghreed Fadhul 3 collaborations

Leila Noetzli 3 collaborations

Ho-Chou Tu 3 collaborations

Joanna Bons 3 collaborations

Jacob Rose 3 collaborations

Christina D King 3 collaborations

Philip A Kern 3 collaborations

Jeremie Boucher 3 collaborations

Brian T O'Neill 3 collaborations

Jason K Kim 3 collaborations

Thiago M Batista 3 collaborations

Nathan R Shelman 3 collaborations

Manoj K Gupta 3 collaborations

Evelyn A Bates 3 collaborations

Harrison A Clarke 3 collaborations

Jennifer L S Willoughby 2 collaborations

Marie H Solheim 2 collaborations

Hui Pan 2 collaborations

Jonathan M Dreyfuss 2 collaborations

Aldons J Lusis 2 collaborations

Calvin Pan 2 collaborations

Manoj Gupta 2 collaborations

Miguel A Lanaspa 2 collaborations

Mary Killian 2 collaborations

Marialena Mouzaki 2 collaborations

Rohit Kohli 2 collaborations

Maria E Moreno-Fernandez 2 collaborations

Genesee J Martinez 2 collaborations

Brian DeBosch 2 collaborations

Mari Saif 2 collaborations

Wilhelmus J Kwanten 2 collaborations

Jessica A Carr 2 collaborations

Ivy X Chen 2 collaborations

Jessica M Posada 2 collaborations

Amitabh Srivastava 2 collaborations

Juanye Zhang 2 collaborations

Yi Zheng 2 collaborations

Matthias Pinter 2 collaborations

Sampurna Chatterjee 2 collaborations

Klaus van Leyen 2 collaborations

Oliver T Bruns 2 collaborations

Rakesh K Jain 2 collaborations

Moungi G Bawendi 2 collaborations

Hans P M M Lauritzen 2 collaborations

Masaji Sakaguchi 2 collaborations

Guoxiao Wang 2 collaborations

Kristina Wallenius 2 collaborations

Gavin O'Mahony 2 collaborations

Lindsey R Conroy 2 collaborations

Laura Herrero 2 collaborations

Mikala M Zelows 2 collaborations

Corissa Cady 2 collaborations

Nikitha Dharanipragada 2 collaborations

Anna E Mead 2 collaborations

Venkateshwari Varadharajan 2 collaborations

Rakhee Banerjee 2 collaborations

Tara R Hawkinson 2 collaborations

Terrymar Medina 2 collaborations

Todd A Lydic 2 collaborations

J Mark Brown 2 collaborations

Gregory A Graf 2 collaborations

Francois Moreau 2 collaborations

Asama Lekbua 1 collaboration

Jodie Ouahed 1 collaboration

Amy E O'Connell 1 collaboration

Stacy A Kahn 1 collaboration

Jeffrey D Goldsmith 1 collaboration

Toshihiko Imamura 1 collaboration

Christine N Duncan 1 collaboration

Judith R Kelsen 1 collaboration

Elizabeth Worthey 1 collaboration

Scott B Snapper 1 collaboration

GuoXiao Wang 1 collaboration

Eric Verdin 1 collaboration

Christopher Newgard 1 collaboration

Kimber L Stanhope 1 collaboration

Richard J Johnson 1 collaboration

Adam J Dugan 1 collaboration

George J Fuchs 1 collaboration

Henrietta Bada 1 collaboration

Erica P Homan 1 collaboration

Bruna B Brandão 1 collaboration

Abdelfattah El Ouaamari 1 collaboration

Michelle S M A Damen 1 collaboration

Traci E Stankiewicz 1 collaboration

Calvin C Chan 1 collaboration

Jessica R Doll 1 collaboration

Sara Szabo 1 collaboration

De'Broski R Herbert 1 collaboration

Justin F Creeden 1 collaboration

Mei Xu 1 collaboration

Robert M Flight 1 collaboration

Hunter N B Moseley 1 collaboration

Wang-Hsin Lee 1 collaboration

Khaled Alganem 1 collaboration

Ali S Imami 1 collaboration

Megan R McMullen 1 collaboration

Sanjoy Roychowdhury 1 collaboration

Atta M Nawabi 1 collaboration

Jennifer A Hipp 1 collaboration

Steven A Weinman 1 collaboration

Robert McCullumsmith 1 collaboration

Laura E Nagy 1 collaboration

Qiwen Kang 1 collaboration

Qingcong Yuan 1 collaboration

Mustafa Kutlu Inci 1 collaboration

Chih-Hao Wang 1 collaboration

Bruna B Brandao 1 collaboration

Rongya Tao 1 collaboration

Michael F Hirshman 1 collaboration

Yingying Yu 1 collaboration

Sujin Suk 1 collaboration

Hye Lim Noh 1 collaboration

Michael Hirshman 1 collaboration

Pasquale Nigro 1 collaboration

Laurie Goodyear 1 collaboration

Jianming Liu 1 collaboration

Martin Varea Romo 1 collaboration

Kishor Acharya 1 collaboration

Phillip Minar 1 collaboration

Lee A Denson 1 collaboration

Hemendra J Vekaria 1 collaboration

Patrick G Sullivan 1 collaboration

María Del Mar Romero 1 collaboration

Meghan Mooring 1 collaboration

Brendan H Fowl 1 collaboration

Shelly Z C Lum 1 collaboration

Ye Liu 1 collaboration

Kangning Yao 1 collaboration

Rory Kirchner 1 collaboration

Aaron Bernstein 1 collaboration

Aatur D Singhi 1 collaboration

Daniel G Jay 1 collaboration

Fernando D Camargo 1 collaboration

Dean Yimlamai 1 collaboration

Guo-Xiao Wang 1 collaboration

Dolors Serra 1 collaboration

Jennifer Willoughby 1 collaboration

Olga Ilkayeva 1 collaboration

Christopher B Newgard 1 collaboration

Bradford W Gibson 1 collaboration

David E Cohen 1 collaboration

Xuemei Zhang 1 collaboration

Rubén García-Martín 1 collaboration

Alfred K Ramirez 1 collaboration

Masahiro Konishi 1 collaboration

Jong Hun Kim 1 collaboration

Syedreza Ali Haider 1 collaboration

Gregory S Bills 1 collaboration

C Prakash Gyawali 1 collaboration

Passisd Laoveeravat 1 collaboration

Jordan Miller 1 collaboration

Mihir S Wagh 1 collaboration

Moamen Gabr 1 collaboration

Keisuke Sawada 1 collaboration

Hak Chung 1 collaboration

Heidrun Vethe 1 collaboration

Tata Nageswara Rao 1 collaboration

Vilas Wagh 1 collaboration

Jun Shirakawa 1 collaboration

Harald Barsnes 1 collaboration

Marc Vaudel 1 collaboration

Tomozumi Takatani 1 collaboration

Sevim Kahraman 1 collaboration

Rachael Martinez 1 collaboration

Jiang Hu 1 collaboration

Yngvild Bjørlykke 1 collaboration

Helge Raeder 1 collaboration

Yoshiyuki Watanabe 1 collaboration

Yoshitomo Morinaga 1 collaboration

Shiro Watanabe 1 collaboration

Allah Nawaz 1 collaboration

Hideki Hatta 1 collaboration

Tomonobu Kado 1 collaboration

Ayumi Nishimura 1 collaboration

Muhammad Bilal 1 collaboration

Muhammad Rahil Aslam 1 collaboration

Keiko Honda 1 collaboration

Yoshimi Nakagawa 1 collaboration

Kenichi Hirabayashi 1 collaboration

Takashi Nakagawa 1 collaboration

Yoshinori Nagai 1 collaboration

Kazuyuki Tobe 1 collaboration

Bruna Brasil Brunao 1 collaboration

Xiang-Yu Liu 1 collaboration

Frederic Tremblay 1 collaboration

Julian Avila-Pacheco 1 collaboration

Clary Clish 1 collaboration

Ronald C Kahn 1 collaboration

Callen Conroy 1 collaboration

Nathan Shelman 1 collaboration

James T Lee 1 collaboration

Roberto Galuppo Monticelli 1 collaboration

Sara Hall 1 collaboration

Mensur Zvekic 1 collaboration

Maddie Herbert 1 collaboration

Alba Morales 1 collaboration

Alessandro Boianelli 1 collaboration

Marie Persson 1 collaboration

Sunhee Jung 1 collaboration

Cholsoon Jang 1 collaboration

Analia S Loria 1 collaboration