Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin.

Animals Biomarkers / metabolism Chronic Disease Disease Progression Female Fluorescence Humans Lipodystrophy / diagnostic imaging Lipofuscin / metabolism Liver / diagnostic imaging Liver Cirrhosis / diagnostic imaging Liver Diseases / diagnostic imaging Male Mice Non-alcoholic Fatty Liver Disease / diagnostic imaging Optical Imaging Spectroscopy, Near-Infrared

Journal

Nature biomedical engineering
ISSN: 2157-846X
Titre abrégé: Nat Biomed Eng
Pays: England
ID NLM: 101696896

Informations de publication

Date de publication:
08 2020
Historique:
received: 21 06 2019
accepted: 13 05 2020
pubmed: 24 6 2020
medline: 18 11 2020
entrez: 24 6 2020
Statut: ppublish

Résumé

Monitoring the progression of non-alcoholic fatty liver disease is hindered by a lack of suitable non-invasive imaging methods. Here, we show that the endogenous pigment lipofuscin displays strong near-infrared and shortwave-infrared fluorescence when excited at 808 nm, enabling label-free imaging of liver injury in mice and the discrimination of pathological processes from normal liver processes with high specificity and sensitivity. We also show that the near-infrared and shortwave-infrared fluorescence of lipofuscin can be used to monitor the progression and regression of liver necroinflammation and fibrosis in mouse models of non-alcoholic fatty liver disease and advanced fibrosis, as well as to detect non-alcoholic steatohepatitis and cirrhosis in biopsied samples of human liver tissue.

Identifiants

DOI: 10.1038/s41551-020-0569-y PMID: 32572196 PMC: PMC8310386
pubmed: 32572196
doi: 10.1038/s41551-020-0569-y
pii: 10.1038/s41551-020-0569-y
pmc: PMC8310386
mid: NIHMS1665952
doi:

Substances chimiques

Biomarkers 0
Lipofuscin 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

801-813

Subventions

Organisme : NIDDK NIH HHS
ID : P30 DK040561
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA126642
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA224348
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007627
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197743
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK036836
Pays : United States
Organisme : NICHD NIH HHS
ID : K12 HD000850
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA080124
Pays : United States
Organisme : NIDDK NIH HHS
ID : R37 DK031036
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK031036
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015871
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA208205
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK033201
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : ErratumIn

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Auteurs

Mari Saif (M)

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.

Wilhelmus J Kwanten (WJ)

Edwin L. Steele Laboratories of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Laboratory of Experimental Medicine and Pediatrics (LEMP)-Gastroenterology and Hepatology, University of Antwerp, Wilrijk, Belgium.
ORCID: 0000-0001-9474-6695

Jessica A Carr (JA)

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.

Ivy X Chen (IX)

Edwin L. Steele Laboratories of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Jessica M Posada (JM)

Edwin L. Steele Laboratories of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

Amitabh Srivastava (A)

Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

Juanye Zhang (J)

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.

Yi Zheng (Y)

Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

Matthias Pinter (M)

Edwin L. Steele Laboratories of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

Sampurna Chatterjee (S)

Edwin L. Steele Laboratories of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Samir Softic (S)

Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Division of Gastroenterology, Boston Children's Hospital, Boston, MA, USA.
Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Kentucky College of Medicine and Kentucky Children's Hospital, Lexington, KY, USA.

C Ronald Kahn (CR)

Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.

Klaus van Leyen (K)

Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

Oliver T Bruns (OT)

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Helmholtz Pioneer Campus, Helmholtz Zentrum München, Neuherberg, Germany.

Rakesh K Jain (RK)

Edwin L. Steele Laboratories of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. jain@steele.mgh.harvard.edu.
ORCID: 0000-0001-7571-3548

Moungi G Bawendi (MG)

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. mgb@mit.edu.
ORCID: 0000-0003-2220-4365

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Non-invasive monitoring of chronic liver...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Non-invasive monitoring of chronic liver...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Non-invasive monitoring of chronic liver...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Non-invasive monitoring of chronic liver...
questionsmedicales.fr › Phénomènes physiques › Phénomènes optiques › Fluorescence › Non-invasive monitoring of chronic liver...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Non-invasive monitoring of chronic liver...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Dermatoses métaboliques › Lipodystrophie › Non-invasive monitoring of chronic liver...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Lipofuscine › Non-invasive monitoring of chronic liver...
questionsmedicales.fr › Système digestif › Foie › Non-invasive monitoring of chronic liver...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Cirrhose du foie › Non-invasive monitoring of chronic liver...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Non-invasive monitoring of chronic liver...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Non-invasive monitoring of chronic liver...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Stéatose hépatique › Stéatose hépatique non alcoolique › Non-invasive monitoring of chronic liver...
questionsmedicales.fr › Techniques d'investigation › Imagerie optique › Non-invasive monitoring of chronic liver...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie proche infrarouge › Non-invasive monitoring of chronic liver...