Tissue-Specific Fructose Metabolism in Obesity and Diabetes.
Diabetes
Dyslipidemia
Fructose
Insulin resistance
NAFLD
Sugar
Journal
Current diabetes reports
ISSN: 1539-0829
Titre abrégé: Curr Diab Rep
Pays: United States
ID NLM: 101093791
Informations de publication
Date de publication:
15 10 2020
15 10 2020
Historique:
accepted:
10
09
2020
entrez:
15
10
2020
pubmed:
16
10
2020
medline:
26
2
2021
Statut:
epublish
Résumé
The objective of this review is to provide up-to-date and comprehensive discussion of tissue-specific fructose metabolism in the context of diabetes, dyslipidemia, and nonalcoholic fatty liver disease (NAFLD). Increased intake of dietary fructose is a risk factor for a myriad of metabolic complications. Tissue-specific fructose metabolism has not been well delineated in terms of its contribution to detrimental health effects associated with fructose intake. Since inhibitors targeting fructose metabolism are being developed for the management of NAFLD and diabetes, it is essential to recognize how inability of one tissue to metabolize fructose may affect metabolism in the other tissues. The primary sites of fructose metabolism are the liver, intestine, and kidney. Skeletal muscle and adipose tissue can also metabolize a large portion of fructose load, especially in the setting of ketohexokinase deficiency, the rate-limiting enzyme of fructose metabolism. Fructose can also be sensed by the pancreas and the brain, where it can influence essential functions involved in energy homeostasis. Lastly, fructose is metabolized by the testes, red blood cells, and lens of the eye where it may contribute to infertility, advanced glycation end products, and cataracts, respectively. An increase in sugar intake, particularly fructose, has been associated with the development of obesity and its complications. Inhibition of fructose utilization in tissues primary responsible for its metabolism alters consumption in other tissues, which have not been traditionally regarded as important depots of fructose metabolism.
Identifiants
pubmed: 33057854
doi: 10.1007/s11892-020-01342-8
pii: 10.1007/s11892-020-01342-8
pmc: PMC10208418
mid: NIHMS1831712
doi:
Substances chimiques
Fructose
30237-26-4
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
64Subventions
Organisme : NCCIH NIH HHS
ID : R21 AT010520
Pays : United States
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