Neighborhood poverty predicts altered neural and behavioral response inhibition.
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
received:
21
09
2019
revised:
22
12
2019
accepted:
10
01
2020
pubmed:
15
1
2020
medline:
20
2
2021
entrez:
15
1
2020
Statut:
ppublish
Résumé
Socioeconomic disadvantage during childhood is associated with a myriad of negative adult outcomes. One mechanism through which disadvantage undermines positive outcomes may be by disrupting the development of self-control. The goal of the present study was to examine pathways from three key indicators of socioeconomic disadvantage - low family income, low maternal education, and neighborhood poverty - to neural and behavioral measures of response inhibition. We utilized data from a representative cohort of 215 twins (ages 7-18 years, 70% male) oversampled for exposure to disadvantage, who participated in the Michigan Twins Neurogenetics Study (MTwiNS), a study within the Michigan State University Twin Registry (MSUTR). Our child-friendly Go/No-Go task activated the bilateral inferior frontal gyrus (IFG), and activation during this task predicted behavioral inhibition performance, extending prior work on adults to youth. Critically, we also found that neighborhood poverty, assessed via geocoding, but not family income or maternal education, was associated with IFG activation, a finding that we replicated in an independent sample of disadvantaged youth. Further, we found that neighborhood poverty predicted response inhibition performance via its effect on IFG activation. These results provide the first mechanistic evidence that disadvantaged contexts may undermine self-control via their effect on the brain. The broader neighborhood, beyond familial contexts, may be critically important for this association, suggesting that contexts beyond the home have profound effects on the developing brain and behaviors critical for future health, wealth, and wellbeing.
Identifiants
pubmed: 31935521
pii: S1053-8119(20)30023-9
doi: 10.1016/j.neuroimage.2020.116536
pmc: PMC7065021
mid: NIHMS1559422
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Twin Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
116536Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK092926
Pays : United States
Organisme : NICHD NIH HHS
ID : UH2 HD087979
Pays : United States
Organisme : NIDDK NIH HHS
ID : RC1 DK086376
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK098983
Pays : United States
Organisme : NIH HHS
ID : S10 OD012240
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD093334
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD061356
Pays : United States
Organisme : NIDDK NIH HHS
ID : R21 DK090718
Pays : United States
Organisme : NIMH NIH HHS
ID : UH3 MH114249
Pays : United States
Organisme : NIMH NIH HHS
ID : UG3 MH114249
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no competing financial interests.
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