Haptoglobin genotype and outcome after aneurysmal subarachnoid haemorrhage.
Adolescent
Adult
Aged
Aged, 80 and over
Child
Cohort Studies
DNA Copy Number Variations
/ genetics
Female
Genotype
Haptoglobins
/ genetics
Humans
Intracranial Aneurysm
/ complications
Male
Middle Aged
Polymorphism, Single Nucleotide
/ genetics
Recovery of Function
Subarachnoid Hemorrhage
/ genetics
Survival Rate
Young Adult
Journal
Journal of neurology, neurosurgery, and psychiatry
ISSN: 1468-330X
Titre abrégé: J Neurol Neurosurg Psychiatry
Pays: England
ID NLM: 2985191R
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
22
07
2019
revised:
30
10
2019
accepted:
11
12
2019
pubmed:
16
1
2020
medline:
22
8
2020
entrez:
16
1
2020
Statut:
ppublish
Résumé
After aneurysmal subarachnoid haemorrhage (aSAH), extracellular haemoglobin (Hb) in the subarachnoid space is bound by haptoglobin, neutralising Hb toxicity and helping its clearance. Two exons in the The The HP2 allele associated with a favourable long-term outcome after high-volume but not low-volume aSAH (multivariable logistic regression). However rs2000999 did not predict outcome. The HP2 allele associated with lower CSF haemoglobin-haptoglobin complex levels. The CSF Hb concentration after high-volume and low-volume aSAH was, respectively, higher and lower than the Hb-binding capacity of CSF haptoglobin. The HP2 allele carries a favourable long-term prognosis after high-volume aSAH. Haptoglobin and the Hb clearance pathway are therapeutic targets after aSAH.
Identifiants
pubmed: 31937585
pii: jnnp-2019-321697
doi: 10.1136/jnnp-2019-321697
pmc: PMC7116595
mid: EMS98662
doi:
Substances chimiques
Haptoglobins
0
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
305-313Subventions
Organisme : Medical Research Council
ID : MC_UU_00011/4
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L01453X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19009
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102215
Pays : United Kingdom
Organisme : Cancer Research UK
ID : A19169
Pays : United Kingdom
Organisme : Medical Research Council
ID : G9815508
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102215/2/13/2
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C18281/A19169
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_15018
Pays : United Kingdom
Informations de copyright
© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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