Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection.

Biomarkers / blood C-Reactive Protein / metabolism Cohort Studies HIV Infections / immunology HIV-1 / physiology Humans Immunity, Innate / genetics Interferon Regulatory Factors / genetics Lipopolysaccharide Receptors / metabolism Lymphocyte Activation Mucosal-Associated Invariant T Cells / immunology Receptors, Antigen, T-Cell / genetics Transcriptome Viremia / immunology

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
14 01 2020
Historique:
received: 14 03 2019
accepted: 10 12 2019
entrez: 16 1 2020
pubmed: 16 1 2020
medline: 24 4 2020
Statut: epublish

Résumé

Mucosa-associated invariant T (MAIT) cell loss in chronic HIV-1 infection is a significant insult to antimicrobial immune defenses. Here we investigate the response of MAIT cells during acute HIV-1 infection utilizing the RV217 cohort with paired longitudinal pre- and post-infection samples. MAIT cells are activated and expand in blood and mucosa coincident with peak HIV-1 viremia, in a manner associated with emerging microbial translocation. This is followed by a phase with elevated function as viral replication is controlled to a set-point level, and later by their functional decline at the onset of chronic infection. Interestingly, enhanced innate-like pathways and characteristics develop progressively in MAIT cells during infection, in parallel with TCR repertoire alterations. These findings delineate the dynamic MAIT cell response to acute HIV-1 infection, and show how the MAIT compartment initially responds and expands with enhanced function, followed by progressive reprogramming away from TCR-dependent antibacterial responses towards innate-like functionality.

Identifiants

DOI: 10.1038/s41467-019-13975-9 PMID: 31937782 PMC: PMC6959336
pubmed: 31937782
doi: 10.1038/s41467-019-13975-9
pii: 10.1038/s41467-019-13975-9
pmc: PMC6959336
doi:

Substances chimiques

Biomarkers 0
CD14 protein, human 0
Interferon Regulatory Factors 0
Lipopolysaccharide Receptors 0
Receptors, Antigen, T-Cell 0
interferon regulatory factor-4 0
C-Reactive Protein 9007-41-4

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

272

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK108350
Pays : United States
Organisme : U.S. Department of Defense (United States Department of Defense)
ID : W81XWH-07-2-0067
Pays : International

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Auteurs

Kerri G Lal (KG)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

Dohoon Kim (D)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
ORCID: 0000-0002-5794-6222

Margaret C Costanzo (MC)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.

Matthew Creegan (M)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.

Edwin Leeansyah (E)

Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Program in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore.

Joana Dias (J)

Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

Dominic Paquin-Proulx (D)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
ORCID: 0000-0003-1407-3414

Leigh Anne Eller (LA)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.

Alexandra Schuetz (A)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Department of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.

Yuwadee Phuang-Ngern (Y)

Department of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.

Shelly J Krebs (SJ)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
ORCID: 0000-0003-1136-1760

Bonnie M Slike (BM)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.

Hannah Kibuuka (H)

Makerere University Walter Reed Project, Kampala, Uganda.

Lucas Maganga (L)

National Institute for Medical Research-Mbeya Medical Research Center, Mbeya, Tanzania.

Sorachai Nitayaphan (S)

Royal Thai Army Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.

Josphat Kosgei (J)

Kenya Medical Research Institute/U.S. Army Medical Research Directorate-Africa/Kenya, Kericho, Kenya.

Carlo Sacdalan (C)

SEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
ORCID: 0000-0002-5839-4837

Jintanat Ananworanich (J)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
SEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
ORCID: 0000-0003-1369-3224

Diane L Bolton (DL)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.

Nelson L Michael (NL)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.

Barbara L Shacklett (BL)

Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, CA, USA.
ORCID: 0000-0002-7067-732X

Merlin L Robb (ML)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.

Michael A Eller (MA)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
ORCID: 0000-0003-3905-4877

Johan K Sandberg (JK)

Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden. johan.sandberg@ki.se.
ORCID: 0000-0002-6275-0750

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Dynamic MAIT cell response with progressively...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Immunoprotéines › Protéine C-réactive › Dynamic MAIT cell response with progressively...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Dynamic MAIT cell response with progressively...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Dynamic MAIT cell response with progressively...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › Dynamic MAIT cell response with progressively...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Dynamic MAIT cell response with progressively...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Dynamic MAIT cell response with progressively...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de régulation d'interféron › Dynamic MAIT cell response with progressively...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des myélomonocytes › Antigènes CD14 › Dynamic MAIT cell response with progressively...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Dynamic MAIT cell response with progressively...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Cellules T invariantes associées aux muqueuses › Dynamic MAIT cell response with progressively...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › Dynamic MAIT cell response with progressively...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Dynamic MAIT cell response with progressively...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Sepsie › Virémie › Dynamic MAIT cell response with progressively...