Diaminated Starch: A Competitor of Chitosan with Highly Mucoadhesive Properties due to Increased Local Cationic Charge Density.
Journal
Biomacromolecules
ISSN: 1526-4602
Titre abrégé: Biomacromolecules
Pays: United States
ID NLM: 100892849
Informations de publication
Date de publication:
10 02 2020
10 02 2020
Historique:
pubmed:
16
1
2020
medline:
1
4
2021
entrez:
16
1
2020
Statut:
ppublish
Résumé
The purpose of this study was to synthesize diaminated starch as a novel mucoadhesive polymer. Starch was tosylated and then reacted with ethylenediamine. The degree of amination was determined by 2,4,6-trinitrobenzene sulfonic acid assay. Properties of diaminated starch including solubility, cytotoxicity, swelling behavior, and mucoadhesion were compared to chitosan. Diaminated starch displayed 2083 ± 121.6 μmol of diamine substructures/g of polymer. At pH 6, diaminated starch exhibited a ζ potential of 6 mV, whereas it was close to zero in the case of unmodified starch. In addition, diaminated starch displayed water solubility over the entire pH range and minor cytotoxicity. The novel polymer showed pronounced swelling behavior in water increasing its initial weight 18- and 6-fold at pH 5 and 6, respectively. Moreover, diaminated starch exhibited 92-fold higher-mucoadhesivity properties than those of chitosan. According to these results, diaminated starch might be a promising novel excipient for the design of mucoadhesive formulations.
Identifiants
pubmed: 31940199
doi: 10.1021/acs.biomac.9b01665
pmc: PMC7205387
doi:
Substances chimiques
Adhesives
0
Cations
0
Diamines
0
Starch
9005-25-8
Chitosan
9012-76-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
999-1008Références
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