Supercharged Proteins and Polypeptides.

adaptive soft matter electrostatic interactions functional assembly supercharged proteins supercharged unstructured polypeptides

Journal

Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358

Informations de publication

Date de publication:
May 2020
Historique:
received: 16 08 2019
revised: 10 10 2019
pubmed: 17 1 2020
medline: 26 2 2021
entrez: 17 1 2020
Statut: ppublish

Résumé

Electrostatic interactions play a vital role in nature. Biomacromolecules such as proteins are orchestrated by electrostatics, among other intermolecular forces, to assemble and organize biochemistry. Natural proteins with a high net charge exist in a folded state or are unstructured and can be an inspiration for scientists to artificially supercharge other protein entities. Recent findings show that supercharging proteins allows for control of their properties such as temperature resistance and catalytic activity. One elegant method to transfer the favorable properties of supercharged proteins to other proteins is the fabrication of fusions. Genetically engineered, supercharged unstructured polypeptides (SUPs) are just one promising fusion tool. SUPs can also be complexed with artificial entities to yield thermotropic and lyotropic liquid crystals and liquids. These architectures represent novel bulk materials that are sensitive to external stimuli. Interestingly, SUPs undergo fluid-fluid phase separation to form coacervates. These coacervates can even be directly generated in living cells or can be combined with dissipative fiber assemblies that induce life-like features. Supercharged proteins and SUPs are developed into exciting classes of materials. Their synthesis, structures, and properties are summarized. Moreover, potential applications are highlighted and challenges are discussed.

Identifiants

pubmed: 31943419
doi: 10.1002/adma.201905309
doi:

Substances chimiques

Peptides 0
Proteins 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e1905309

Subventions

Organisme : Zernike Institute for Advanced Materials
Organisme : DWI - Leibniz Institute for Interactive Materials
Organisme : Netherlands Organization for Scientific Research
ID : 723.015.002
Organisme : European Research Council
ID : 694610
Pays : International

Informations de copyright

© 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Auteurs

Chao Ma (C)

Zernike Institute for Advanced Materials, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.

Anke Malessa (A)

Zernike Institute for Advanced Materials, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.

Arnold J Boersma (AJ)

DWI - Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, 52056, Aachen, Germany.

Kai Liu (K)

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 130022, Changchun, China.

Andreas Herrmann (A)

Zernike Institute for Advanced Materials, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
DWI - Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, 52056, Aachen, Germany.
Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Worringerweg 2, 52074, Aachen, Germany.

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Classifications MeSH