PRR adjuvants restrain high stability peptides presentation on APCs.
Animals
Adjuvants, Immunologic
/ pharmacology
Mice
Antigen-Presenting Cells
/ immunology
Antigen Presentation
/ drug effects
Peptides
/ immunology
Mice, Inbred C57BL
Female
Immunodominant Epitopes
/ immunology
CD4-Positive T-Lymphocytes
/ immunology
Th1 Cells
/ immunology
Histocompatibility Antigens Class II
/ immunology
T-cell
adjuvants
immunization
immunology
infectious disease
inflammation
microbiology
mouse
vaccine
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
30 Oct 2024
30 Oct 2024
Historique:
medline:
30
10
2024
pubmed:
30
10
2024
entrez:
30
10
2024
Statut:
epublish
Résumé
Adjuvants can affect APCs function and boost adaptive immune responses post-vaccination. However, whether they modulate the specificity of immune responses, particularly immunodominant epitope responses, and the mechanisms of regulating antigen processing and presentation remain poorly defined. Here, using overlapping synthetic peptides, we screened the dominant epitopes of Th1 responses in mice post-vaccination with different adjuvants and found that the adjuvants altered the antigen-specific CD4
Identifiants
pubmed: 39475096
doi: 10.7554/eLife.99173
pii: 99173
doi:
pii:
Substances chimiques
Adjuvants, Immunologic
0
Peptides
0
Immunodominant Epitopes
0
Histocompatibility Antigens Class II
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Nature Science Foundation of China
ID : 82001751
Organisme : Futian Healthcare Research Project
ID : FTWS2021061
Organisme : Futian Healthcare Research Project
ID : FTWS2022063
Organisme : Futian Healthcare Research Project
ID : FTWS028
Informations de copyright
© 2024, Li, Zhang et al.
Déclaration de conflit d'intérêts
BL, JZ, TH, HY, HW, PW, CW No competing interests declared
Références
Nat Rev Dis Primers. 2023 Apr 20;9(1):19
pubmed: 37081005
J Immunol. 1992 Sep 15;149(6):1905-11
pubmed: 1517561
Vaccines (Basel). 2022 Jul 13;10(7):
pubmed: 35891284
Drug Saf. 2015 Nov;38(11):1059-74
pubmed: 26446142
Nat Immunol. 2008 Nov;9(11):1208-10
pubmed: 18936779
Vaccine. 2015 Jul 31;33(32):3953-62
pubmed: 26093202
J Vis Exp. 2014 Mar 25;(85):
pubmed: 24686319
Mol Aspects Med. 2023 Aug;92:101183
pubmed: 37018869
Oncotarget. 2017 Jul 12;8(40):68138-68152
pubmed: 28978104
J Immunol. 2020 Aug 1;205(3):699-707
pubmed: 32591402
Infect Immun. 2000 Jun;68(6):3079-89
pubmed: 10816447
J Immunol. 2006 Mar 15;176(6):3548-56
pubmed: 16517723
Trends Biotechnol. 2019 Apr;37(4):373-388
pubmed: 30470547
J Immunol. 2005 Nov 1;175(9):5940-9
pubmed: 16237087
J Immunol. 2005 Sep 15;175(6):3715-23
pubmed: 16148117
Front Immunol. 2022 May 16;13:878271
pubmed: 35651601
Eur J Immunol. 2006 Dec;36(12):3346-55
pubmed: 17109467
Blood. 2005 Mar 15;105(6):2465-72
pubmed: 15546948
Semin Immunol. 2018 Oct;39:14-21
pubmed: 29801750
Nat Rev Immunol. 2002 Feb;2(2):85-95
pubmed: 11910899
Expert Rev Vaccines. 2017 Jan;16(1):55-63
pubmed: 27448771
J Immunol. 1998 Feb 15;160(4):1555-64
pubmed: 9469410
Vaccines (Basel). 2014 Apr 14;2(2):297-322
pubmed: 26344621
Immunol Rev. 2004 Jun;199:227-50
pubmed: 15233738
Eur J Med Chem. 2022 Jan 5;227:113917
pubmed: 34688011
Front Oncol. 2022 Sep 27;12:970967
pubmed: 36237313
Gastroenterology. 2024 Feb;166(2):267-283
pubmed: 37806461
J Exp Med. 1999 Feb 15;189(4):701-10
pubmed: 9989985
Cell Immunol. 2009;255(1-2):41-5
pubmed: 19036358
J Exp Med. 2001 Apr 16;193(8):881-92
pubmed: 11304549
Immunity. 2008 May;28(5):698-709
pubmed: 18450485
Cancer Immunol Immunother. 2019 Nov;68(11):1881-1889
pubmed: 31595324
Nature. 2017 May 11;545(7653):243-247
pubmed: 28467828
Cell. 2021 Jul 22;184(15):3962-3980.e17
pubmed: 34171305
J Immunol. 2005 May 15;174(10):5994-6004
pubmed: 15879092
J Immunol. 2010 Jan 15;184(2):573-81
pubmed: 20007533
J Vis Exp. 2021 Oct 15;(176):
pubmed: 34723952
Cell. 2022 Feb 17;185(4):614-629.e21
pubmed: 35148840
Immunol Rev. 2005 Oct;207:261-78
pubmed: 16181342
Autoimmun Rev. 2004 Nov;3(7-8):487-92
pubmed: 15546795
Sci Rep. 2015 Oct 05;5:14793
pubmed: 26434384
Front Immunol. 2017 Sep 25;8:1175
pubmed: 28993770