S1P d20:1, an endogenous modulator of S1P d18:1/S1P
Animals
Blotting, Western
CHO Cells
Cell Line, Tumor
Central Nervous System
/ metabolism
Chromatography, Liquid
Cricetulus
Cyclooxygenase 2
/ metabolism
Glioblastoma
/ metabolism
Humans
Lysophospholipids
/ metabolism
Mice
Polymerase Chain Reaction
Signal Transduction
/ genetics
Sphingosine
/ analogs & derivatives
Sphingosine-1-Phosphate Receptors
/ metabolism
Tandem Mass Spectrometry
S1P receptors
brain
cyclooxygenase 2
glioblastoma cells
sphingosine 1-phosphate
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
24
09
2019
revised:
27
12
2019
accepted:
27
12
2019
pubmed:
17
1
2020
medline:
26
1
2021
entrez:
17
1
2020
Statut:
ppublish
Résumé
Sphingosine 1-phosphate (S1P) signaling influences numerous cell biological mechanisms such as differentiation, proliferation, survival, migration, and angiogenesis. Intriguingly, our current knowledge is based solely on the role of S1P with an 18-carbon long-chain base length, S1P d18:1. Depending on the composition of the first and rate-limiting enzyme of the sphingolipid de novo metabolism, the serine palmitoyltransferase, other chain lengths have been described in vivo. While cells are also able to produce S1P d20:1, its abundance and function remains elusive so far. Our experiments are highlighting the role of S1P d20:1 in the mouse central nervous system (CNS) and human glioblastoma. We show here that S1P d20:1 and its precursors are detectable in both healthy mouse CNS-tissue and human glioblastoma. On the functional level, we focused our work on one particular, well-characterized pathway, the induction of cyclooxygenase (COX)-2 expression via the S1P receptor 2 (S1P
Identifiants
pubmed: 31944406
doi: 10.1096/fj.201902391R
doi:
Substances chimiques
Lysophospholipids
0
Sphingosine-1-Phosphate Receptors
0
sphingosine 1-phosphate
26993-30-6
Ptgs2 protein, mouse
EC 1.14.99.-
Cyclooxygenase 2
EC 1.14.99.1
Sphingosine
NGZ37HRE42
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3932-3942Informations de copyright
© 2020 The Authors. The FASEB Journal published by Wiley Periodicals, Inc. on behalf of Federation of American Societies for Experimental Biology.
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