Patch testing in Lao medical students.
2-Naphthylamine
/ adverse effects
Adolescent
Adult
Allergens
/ adverse effects
Balsams
/ adverse effects
Cobalt
/ adverse effects
Dermatitis, Allergic Contact
/ diagnosis
Epoxy Resins
/ adverse effects
Female
Gold
/ adverse effects
Humans
Laos
Male
Middle Aged
Nickel
/ adverse effects
Patch Tests
Phenylenediamines
/ adverse effects
Resins, Synthetic
/ adverse effects
Students, Medical
Thimerosal
/ adverse effects
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
05
2019
accepted:
30
12
2019
entrez:
17
1
2020
pubmed:
17
1
2020
medline:
3
4
2020
Statut:
epublish
Résumé
Dermatological services in Laos, South East Asia are limited to the capital and patch testing is currently not available, so no data exists regarding the common cutaneous allergens in this population. The aim of this study was to document positive patch tests in medical students without evidence of contact dermatitis in Laos. One hundred and fifty medical students were patch tested using TRUE Test® panels 1 to 3 (35 allergens). Readings were taken at Days 2 and 4. Thirty-eight students (25.3%) had a positive reaction to at least one allergen, accounting for 52 reactions in total. The proportion of the students with positive patch test reading was significantly higher in the female [33/96 (34%)] than in the male [5/54 (9%)], p<0.001. The most common allergens were: nickel (10%), gold (6.6%), thiomersal (6.6%), cobalt dichloride (2%) and p-tert-Butylphenol formaldehyde resin (2%). Balsam of Peru (0.66%), black rubber mix (0.66%), Cl+Me-Isothiazolinone (0.66%), fragrance mix 1 (0.66%), quinolone mix (0.66%), methyldibromo glutaronitrile (0.66%), mercapto mix (0.66%), epoxy resin (0.66%), paraben mix (0.66%), thiuram (0.66%) and wool alcohols (0.66%) accounted for all of the other positive reactions. This study represents the first documented patch test results in Lao medical students and in the adult Lao population. The results of this study will inform any future research into contact allergy in Laos and give an insight into the background level of contact sensitivity in this population.
Sections du résumé
BACKGROUND
Dermatological services in Laos, South East Asia are limited to the capital and patch testing is currently not available, so no data exists regarding the common cutaneous allergens in this population.
OBJECTIVES
The aim of this study was to document positive patch tests in medical students without evidence of contact dermatitis in Laos.
PATIENTS/MATERIALS/METHODS
One hundred and fifty medical students were patch tested using TRUE Test® panels 1 to 3 (35 allergens). Readings were taken at Days 2 and 4.
RESULTS
Thirty-eight students (25.3%) had a positive reaction to at least one allergen, accounting for 52 reactions in total. The proportion of the students with positive patch test reading was significantly higher in the female [33/96 (34%)] than in the male [5/54 (9%)], p<0.001. The most common allergens were: nickel (10%), gold (6.6%), thiomersal (6.6%), cobalt dichloride (2%) and p-tert-Butylphenol formaldehyde resin (2%). Balsam of Peru (0.66%), black rubber mix (0.66%), Cl+Me-Isothiazolinone (0.66%), fragrance mix 1 (0.66%), quinolone mix (0.66%), methyldibromo glutaronitrile (0.66%), mercapto mix (0.66%), epoxy resin (0.66%), paraben mix (0.66%), thiuram (0.66%) and wool alcohols (0.66%) accounted for all of the other positive reactions.
CONCLUSION
This study represents the first documented patch test results in Lao medical students and in the adult Lao population. The results of this study will inform any future research into contact allergy in Laos and give an insight into the background level of contact sensitivity in this population.
Identifiants
pubmed: 31945067
doi: 10.1371/journal.pone.0217192
pii: PONE-D-19-12753
pmc: PMC6964850
doi:
Substances chimiques
Allergens
0
Balsams
0
Epoxy Resins
0
Phenylenediamines
0
Resins, Synthetic
0
black rubber
0
Thimerosal
2225PI3MOV
p-tert-butylphenolformaldehyde resin
25085-50-1
Cobalt
3G0H8C9362
Gold
7440-57-5
Nickel
7OV03QG267
Peruvian balsam
8P5F881OCY
2-Naphthylamine
CKR7XL41N4
cobaltous chloride
EVS87XF13W
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0217192Commentaires et corrections
Type : ErratumIn
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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pubmed: 27362404
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pubmed: 21309787
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pubmed: 28473674
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pubmed: 7842673
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pubmed: 28244094