Models of protein production along the cell cycle: An investigation of possible sources of noise.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
02
04
2019
accepted:
18
11
2019
entrez:
17
1
2020
pubmed:
17
1
2020
medline:
9
4
2020
Statut:
epublish
Résumé
In this article, we quantitatively study, through stochastic models, the effects of several intracellular phenomena, such as cell volume growth, cell division, gene replication as well as fluctuations of available RNA polymerases and ribosomes. These phenomena are indeed rarely considered in classic models of protein production and no relative quantitative comparison among them has been performed. The parameters for a large and representative class of proteins are determined using experimental measures. The main important and surprising conclusion of our study is to show that despite the significant fluctuations of free RNA polymerases and free ribosomes, they bring little variability to protein production contrary to what has been previously proposed in the literature. After verifying the robustness of this quite counter-intuitive result, we discuss its possible origin from a theoretical view, and interpret it as the result of a mean-field effect.
Identifiants
pubmed: 31945071
doi: 10.1371/journal.pone.0226016
pii: PONE-D-19-09304
pmc: PMC6964835
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0226016Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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