NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain.
Aged
Aged, 80 and over
Aging
Alzheimer Disease
/ metabolism
Antigens, CD
/ metabolism
Antigens, Differentiation, Myelomonocytic
/ metabolism
Astrocytes
/ cytology
Brain
/ metabolism
DNA Damage
Excitatory Amino Acid Transporter 2
/ metabolism
Gene Expression Regulation
Glial Fibrillary Acidic Protein
/ metabolism
Glutamate-Ammonia Ligase
/ metabolism
Humans
Microglia
/ metabolism
Neurofibrillary Tangles
/ metabolism
Tumor Suppressor Proteins
/ genetics
tau Proteins
/ metabolism
N-myc downstream regulated gene 2 (NDRG2)
ageing brain
astrocyte
neurofibrillary tangles
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 Jan 2020
04 Jan 2020
Historique:
received:
12
12
2019
accepted:
02
01
2020
entrez:
18
1
2020
pubmed:
18
1
2020
medline:
3
6
2020
Statut:
epublish
Résumé
Astrocytes play a major role in the pathogenesis of a range of neurodegenerative diseases, including Alzheimer's disease (AD), undergoing dramatic morphological and molecular changes that can cause potentially both beneficial and detrimental effects. They comprise a heterogeneous population, requiring a panel of specific phenotype markers to identify astrocyte subtypes, changes in function and their relation to pathology. This study aimed to characterise expression of the astrocyte marker N-myc downstream regulated gene 2 (NDRG2) in the ageing brain, investigate the relationship between NDRG2 and a panel of astrocyte markers, and relate NDRG2 expression to pathology. NDRG2 specifically immunolabelled the cell body and radiating processes of astrocytes in the temporal cortex of the Cognitive Function and Ageing Study (CFAS) neuropathology cohort. Expression of NDRG2 did not correlate with other astrocyte markers, including glial fibrillary acidic protein (GFAP), excitatory amino acid transporter 2 (EAAT2) and glutamine synthetase (GS). NDRG2 showed a relationship to AT8
Identifiants
pubmed: 31947996
pii: ijms21010340
doi: 10.3390/ijms21010340
pmc: PMC6982267
pii:
doi:
Substances chimiques
Antigens, CD
0
Antigens, Differentiation, Myelomonocytic
0
CD68 antigen, human
0
Excitatory Amino Acid Transporter 2
0
Glial Fibrillary Acidic Protein
0
NDRG2 protein, human
0
Tumor Suppressor Proteins
0
tau Proteins
0
Glutamate-Ammonia Ligase
EC 6.3.1.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : King Abdulaziz University
ID : -
Organisme : Medical Research Council
ID : G0601022
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0900582
Pays : United Kingdom
Organisme : Medical Research Council
ID : G9901400
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0300126
Pays : United Kingdom
Références
Acta Neuropathol. 2010 Jan;119(1):7-35
pubmed: 20012068
Adv Exp Med Biol. 2019;1175:273-324
pubmed: 31583592
Glia. 2018 Jul;66(7):1432-1446
pubmed: 29476556
Neurochem Int. 2011 Aug;59(1):21-7
pubmed: 21672576
Neuroreport. 2008 Jun 11;19(9):927-31
pubmed: 18520995
J Neurosci. 2002 Jan 1;22(1):183-92
pubmed: 11756501
J Neurochem. 2014 Aug;130(3):374-87
pubmed: 24697507
Acta Neuropathol. 2002 Jan;103(1):20-5
pubmed: 11837743
Neurobiol Aging. 1997 Jul-Aug;18(4 Suppl):S91-4
pubmed: 9330994
Acta Neuropathol. 1991;82(4):239-59
pubmed: 1759558
Neuropathol Appl Neurobiol. 2010 Feb;36(1):25-40
pubmed: 19422529
Behav Brain Res. 2020 Feb 3;379:112384
pubmed: 31778735
J Neuroinflammation. 2016 Jun 02;13(1):135
pubmed: 27256292
Neurobiol Dis. 2004 Jun;16(1):48-58
pubmed: 15207261
Biomed Res Int. 2019 Jun 24;2019:9605265
pubmed: 31341912
Mol Neurobiol. 2017 Jul;54(5):3286-3299
pubmed: 27154863
J Alzheimers Dis. 2015;45(4):1001-14
pubmed: 25663025
Acta Biochim Biophys Sin (Shanghai). 2015 Oct;47(10):761-6
pubmed: 26341979
Mol Cell Biochem. 2002 Jan;229(1-2):35-44
pubmed: 11936845
PLoS One. 2013;8(2):e57130
pubmed: 23451161
Mol Neurobiol. 2014 Oct;50(2):305-13
pubmed: 24390566
J Neurosci. 2009 Mar 11;29(10):3276-87
pubmed: 19279265
J Proteome Res. 2010 Dec 3;9(12):6368-79
pubmed: 20886841
CNS Neurosci Ther. 2017 Aug;23(8):667-679
pubmed: 28670853
J Neurochem. 2001 May;77(3):705-19
pubmed: 11331400
Psychol Med. 1998 Mar;28(2):319-35
pubmed: 9572090
J Cell Physiol. 2019 Nov;234(11):20847-20858
pubmed: 31004356
Neurobiol Aging. 2010 Apr;31(4):578-90
pubmed: 18586353
Trends Neurosci. 2006 Oct;29(10):547-53
pubmed: 16938356
Neurosci Lett. 2015 Nov 16;609:11-7
pubmed: 26455863
J Neurodegener Dis. 2013;2013:234572
pubmed: 26316984
Cell Tissue Res. 2014 Jul;357(1):31-41
pubmed: 24816982
J Alzheimers Dis. 2011;25(2):359-72
pubmed: 21422529
Neuropathol Appl Neurobiol. 2017 Jun;43(4):281-298
pubmed: 27442752
Ann Neurol. 1996 Nov;40(5):759-66
pubmed: 8957017
Int J Cancer. 2003 Sep 1;106(3):342-7
pubmed: 12845671
J Histochem Cytochem. 2008 Feb;56(2):175-82
pubmed: 17998568
Transl Stroke Res. 2019 Jun 27;:null
pubmed: 31250377
Trends Neurosci. 1999 May;22(5):208-15
pubmed: 10322493
Neurotherapeutics. 2010 Oct;7(4):399-412
pubmed: 20880504
J Biol Chem. 2011 Apr 8;286(14):12450-60
pubmed: 21247902