Generating stem-like memory T cells with antioxidants for adoptive cell transfer immunotherapy of cancer.
Adoptive cell transfer
Antioxidant metabolism
CAR
CD8 T cell
Cancer immunotherapy
Memory
Memory stem cell
N-acetylcysteine
Naïve
Reactive oxygen species
Journal
Methods in enzymology
ISSN: 1557-7988
Titre abrégé: Methods Enzymol
Pays: United States
ID NLM: 0212271
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
18
1
2020
pubmed:
18
1
2020
medline:
5
1
2021
Statut:
ppublish
Résumé
Among the multiple factors that are responsible for the success of adoptive cell transfer (ACT) immunotherapy for cancer, the differentiation status of the in vitro expanded T cell product at the time of transfer seems to play a major role. In particular, less differentiated memory CD8
Identifiants
pubmed: 31948545
pii: S0076-6879(19)30361-1
doi: 10.1016/bs.mie.2019.08.016
pii:
doi:
Substances chimiques
Antioxidants
0
Acetylcysteine
WYQ7N0BPYC
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
137-158Informations de copyright
© 2020 Elsevier Inc. All rights reserved.