The Cap-Snatching Mechanism of Bunyaviruses.

Endonucleases / chemistry Orthobunyavirus / genetics Orthomyxoviridae / genetics RNA Caps / genetics RNA, Viral / genetics Transcription, Genetic Viral Proteins / metabolism Virus Replication
bunyavirus cap binding cap snatching endonuclease viral transcription

Journal

Trends in microbiology
ISSN: 1878-4380
Titre abrégé: Trends Microbiol
Pays: England
ID NLM: 9310916

Informations de publication

Date de publication:
04 2020
Historique:
received: 26 11 2019
accepted: 09 12 2019
pubmed: 18 1 2020
medline: 8 6 2021
entrez: 18 1 2020
Statut: ppublish

Résumé

In common with all segmented negative-sense RNA viruses, bunyavirus transcripts contain heterologous sequences at their 5' termini originating from capped host cell RNAs. These heterologous sequences are acquired by a so-called cap-snatching mechanism. Whereas for nuclear replicating influenza virus the source of capped primers as well as the cap-binding and endonuclease activities of the viral polymerase needed for cap snatching have been functionally and structurally well characterized, our knowledge on the expected counterparts of cytoplasmic replicating bunyaviruses is still limited and controversial. This review focuses on the cap-snatching mechanism of bunyaviruses in the light of recent structural and functional data.

Identifiants

DOI: 10.1016/j.tim.2019.12.006 PMID: 31948728
pubmed: 31948728
pii: S0966-842X(19)30321-X
doi: 10.1016/j.tim.2019.12.006
pii:
doi:

Substances chimiques

RNA Caps 0
RNA, Viral 0
Viral Proteins 0
Endonucleases EC 3.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

293-303

Informations de copyright

Copyright © 2019 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Auteurs

Silke Olschewski (S)

Bernhard Nocht Institute for Tropical Medicine, Department of Virology, Hamburg, Germany.

Stephen Cusack (S)

European Molecular Biology Laboratory, Grenoble, France.

Maria Rosenthal (M)

Bernhard Nocht Institute for Tropical Medicine, Department of Virology, Hamburg, Germany. Electronic address: rosenthal@bnitm.de.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Endonucleases › The Cap-Snatching Mechanism of Bunyaviruses.
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Bunyaviridae › Orthobunyavirus › The Cap-Snatching Mechanism of Bunyaviruses.
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Orthomyxoviridae › The Cap-Snatching Mechanism of Bunyaviruses.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides guanyliques › Coiffes des ARN › The Cap-Snatching Mechanism of Bunyaviruses.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN viral › The Cap-Snatching Mechanism of Bunyaviruses.
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › The Cap-Snatching Mechanism of Bunyaviruses.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › The Cap-Snatching Mechanism of Bunyaviruses.
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › The Cap-Snatching Mechanism of Bunyaviruses.