Opposing Contributions of GABAergic and Glutamatergic Ventral Pallidal Neurons to Motivational Behaviors.
GABAergic neurons
glutamatergic neurons
negative motivation
positive motivation
punishment avoidance
reward seeking
ventral pallidum
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
04 03 2020
04 03 2020
Historique:
received:
30
03
2019
revised:
23
09
2019
accepted:
04
12
2019
pubmed:
18
1
2020
medline:
8
7
2020
entrez:
18
1
2020
Statut:
ppublish
Résumé
The ventral pallidum (VP) is critical for invigorating reward seeking and is also involved in punishment avoidance, but how it contributes to such opposing behavioral actions remains unclear. Here, we show that GABAergic and glutamatergic VP neurons selectively control behavior in opposing motivational contexts. In vivo recording combined with optogenetics in mice revealed that these two populations oppositely encode positive and negative motivational value, are differentially modulated by animal's internal state, and determine the behavioral response during motivational conflict. Furthermore, GABAergic VP neurons are essential for movements toward reward in a positive motivational context but suppress movements in an aversive context. In contrast, glutamatergic VP neurons are essential for movements to avoid a threat but suppress movements in an appetitive context. Our results indicate that GABAergic and glutamatergic VP neurons encode the drive for approach and avoidance, respectively, with the balance between their activities determining the type of motivational behavior.
Identifiants
pubmed: 31948733
pii: S0896-6273(19)31048-7
doi: 10.1016/j.neuron.2019.12.006
pmc: PMC8573387
mid: NIHMS1546280
pii:
doi:
Substances chimiques
Glutamic Acid
3KX376GY7L
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
921-933.e5Subventions
Organisme : NIDA NIH HHS
ID : R01 DA050374
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH101214
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH108924
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS104944
Pays : United States
Organisme : NIMH NIH HHS
ID : F32 MH113316
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
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