CSF SerpinA1 in Creutzfeldt-Jakob disease and frontotemporal lobar degeneration.
Journal
Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
12
07
2019
revised:
06
12
2019
accepted:
26
12
2019
pubmed:
21
1
2020
medline:
11
11
2021
entrez:
21
1
2020
Statut:
ppublish
Résumé
SerpinA1 (alpha-1 antitrypsin) is an acute inflammatory protein, which seems to play a role in neurodegeneration and neuroinflammation. In Alzheimer's disease and synucleinopathies, SerpinA1 is overexpressed in the brain and the cerebrospinal fluid (CSF) showing abnormal patterns of its charge isoforms. To date, no comprehensive studies explored SerpinA1 CSF isoforms in Creutzfeldt-Jakob disease (CJD) and frontotemporal lobar degeneration (FTLD). Using a capillary isoelectric focusing immunoassay, we analyzed CSF SerpinA1 isoforms in control cases (n = 31) and patients with a definite or probable diagnosis of CJD (n=77) or FTLD (n = 30), belonging to several disease subtypes. The overall SerpinA1 signal was significantly higher than in controls in CJD subtypes linked to abnormal prion protein (PrP CJD linked to PrP
Identifiants
pubmed: 31957347
doi: 10.1002/acn3.50980
pmc: PMC7034504
doi:
Substances chimiques
Protein Isoforms
0
alpha 1-Antitrypsin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
191-199Subventions
Organisme : EU Joint Programme - Neurodegenerative Disease Research (JPND) network
Pays : International
Organisme : PreFrontAls
ID : 01ED1512
Pays : International
Organisme : the foundation of the state of Baden-Württemberg
ID : D.3830
Pays : International
Organisme : the Thierry Latran foundation
Pays : International
Organisme : German Federal Ministry of Education and Research
ID : FTLDc 01GI1007A
Pays : International
Organisme : BIU
ID : D.5009
Pays : International
Organisme : Italian Ministry of Health
ID : Ricerca corrente
Pays : International
Informations de copyright
© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.
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