S. mediterranea
cell death
developmental biology
neurogenesis
protein kinase
regeneration
signaling
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
20 01 2020
20 01 2020
Historique:
received:
31
03
2019
accepted:
30
12
2019
entrez:
21
1
2020
pubmed:
21
1
2020
medline:
15
4
2021
Statut:
epublish
Résumé
Negative regulators of adult neurogenesis are of particular interest as targets to enhance neuronal repair, but few have yet been identified. Planarians can regenerate their entire CNS using pluripotent adult stem cells, and this process is robustly regulated to ensure that new neurons are produced in proper abundance. Using a high-throughput pipeline to quantify brain chemosensory neurons, we identify the conserved tyrosine kinase
Identifiants
pubmed: 31958270
doi: 10.7554/eLife.47293
pii: 47293
pmc: PMC6970515
doi:
pii:
Substances chimiques
Tec protein-tyrosine kinase
EC 2.7.1.-
Protein-Tyrosine Kinases
EC 2.7.10.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM130835
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM129339
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008061
Pays : United States
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : PGSD3-471547-2015
Organisme : NIH HHS
ID : 1R01GM129339
Pays : United States
Informations de copyright
© 2020, Karge et al.
Déclaration de conflit d'intérêts
AK, NB, SW, CP No competing interests declared
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