Management of cardiac disease in cancer patients throughout oncological treatment: ESMO consensus recommendations.
Clinical Practice Guidelines
cardiac disease
cardiovascular toxicity
diagnosis
recommendations
Journal
Annals of oncology : official journal of the European Society for Medical Oncology
ISSN: 1569-8041
Titre abrégé: Ann Oncol
Pays: England
ID NLM: 9007735
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
23
07
2019
revised:
18
10
2019
accepted:
21
10
2019
entrez:
22
1
2020
pubmed:
22
1
2020
medline:
7
1
2021
Statut:
ppublish
Résumé
Cancer and cardiovascular (CV) disease are the most prevalent diseases in the developed world. Evidence increasingly shows that these conditions are interlinked through common risk factors, coincident in an ageing population, and are connected biologically through some deleterious effects of anticancer treatment on CV health. Anticancer therapies can cause a wide spectrum of short- and long-term cardiotoxic effects. An explosion of novel cancer therapies has revolutionised this field and dramatically altered cancer prognosis. Nevertheless, these new therapies have introduced unexpected CV complications beyond heart failure. Common CV toxicities related to cancer therapy are defined, along with suggested strategies for prevention, detection and treatment. This ESMO consensus article proposes to define CV toxicities related to cancer or its therapies and provide guidance regarding prevention, screening, monitoring and treatment of CV toxicity. The majority of anticancer therapies are associated with some CV toxicity, ranging from asymptomatic and transient to more clinically significant and long-lasting cardiac events. It is critical however, that concerns about potential CV damage resulting from anticancer therapies should be weighed against the potential benefits of cancer therapy, including benefits in overall survival. CV disease in patients with cancer is complex and treatment needs to be individualised. The scope of cardio-oncology is wide and includes prevention, detection, monitoring and treatment of CV toxicity related to cancer therapy, and also ensuring the safe development of future novel cancer treatments that minimise the impact on CV health. It is anticipated that the management strategies discussed herein will be suitable for the majority of patients. Nonetheless, the clinical judgment of physicians remains extremely important; hence, when using these best clinical practices to inform treatment options and decisions, practitioners should also consider the individual circumstances of their patients on a case-by-case basis.
Identifiants
pubmed: 31959335
pii: S0923-7534(19)36080-6
doi: 10.1016/j.annonc.2019.10.023
pmc: PMC8019325
mid: NIHMS1663331
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Practice Guideline
Langues
eng
Sous-ensembles de citation
IM
Pagination
171-190Subventions
Organisme : NCI NIH HHS
ID : R01 CA233610
Pays : United States
Informations de copyright
Copyright © 2019 European Society for Medical Oncology. Published by Elsevier Ltd. All rights reserved.
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