The single-cell pathology landscape of breast cancer.


Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
02 2020
Historique:
received: 07 10 2018
accepted: 01 11 2019
pubmed: 22 1 2020
medline: 12 5 2020
entrez: 22 1 2020
Statut: ppublish

Résumé

Single-cell analyses have revealed extensive heterogeneity between and within human tumours

Identifiants

pubmed: 31959985
doi: 10.1038/s41586-019-1876-x
pii: 10.1038/s41586-019-1876-x
doi:

Substances chimiques

Biomarkers, Tumor 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

615-620

Commentaires et corrections

Type : CommentIn

Références

Wagner, J. et al. A single-cell atlas of the tumor and immune ecosystem of human breast cancer. Cell 177, 1330–1345 (2019).
doi: 10.1016/j.cell.2019.03.005 pubmed: 30982598 pmcid: 6526772
Bedard, P. L., Hansen, A. R., Ratain, M. J. & Siu, L. L. Tumour heterogeneity in the clinic. Nature 501, 355–364 (2013).
doi: 10.1038/nature12627 pubmed: 24048068 pmcid: 5224525
Dagogo-Jack, I. & Shaw, A. T. Tumour heterogeneity and resistance to cancer therapies. Nat. Rev. Clin. Oncol. 15, 81–94 (2018).
doi: 10.1038/nrclinonc.2017.166 pubmed: 29115304
McGranahan, N. & Swanton, C. Biological and therapeutic impact of intratumor heterogeneity in cancer evolution. Cancer Cell 27, 15–26 (2015).
doi: 10.1016/j.ccell.2014.12.001 pubmed: 25584892
Giesen, C. et al. Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry. Nat. Methods 11, 417–422 (2014).
doi: 10.1038/nmeth.2869 pubmed: 24584193
Coates, A. S. et al. Tailoring therapies—improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015. Ann. Oncol. 26, 1533–1546 (2015).
doi: 10.1093/annonc/mdv221 pubmed: 25939896 pmcid: 4511219
Hammond, M. E. H. et al. American Society of Clinical Oncology/College Of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. J. Clin. Oncol. 28, 2784–2795 (2010).
doi: 10.1200/JCO.2009.25.6529 pubmed: 20404251 pmcid: 2881855
Wolff, A. C. et al. Human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline focused update. J. Clin. Oncol. 36, 2105–2122 (2018).
doi: 10.1200/JCO.2018.77.8738 pubmed: 29846122
Curtis, C. et al. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature 486, 346–352 (2012).
doi: 10.1038/nature10983 pubmed: 22522925 pmcid: 3440846
Sørlie, T. et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl Acad. Sci. USA 98, 10869–10874 (2001).
doi: 10.1073/pnas.191367098 pubmed: 11553815 pmcid: 58566
Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature 490, 61–70 (2012).
doi: 10.1038/nature11412
Beck, A. H. et al. Systematic analysis of breast cancer morphology uncovers stromal features associated with survival. Sci. Transl. Med. 3, 108ra113 (2011).
doi: 10.1126/scitranslmed.3002564 pubmed: 22072638
Focke, C. M., Decker, T. & van Diest, P. J. Intratumoral heterogeneity of Ki67 expression in early breast cancers exceeds variability between individual tumours. Histopathology 69, 849–861 (2016).
doi: 10.1111/his.13007 pubmed: 27270560
Rye, I. H. et al. Intratumor heterogeneity defines treatment-resistant HER2+ breast tumors. Mol. Oncol. 12, 1838–1855 (2018).
doi: 10.1002/1878-0261.12375 pubmed: 30133130 pmcid: 6210052
Angelo, M. et al. Multiplexed ion beam imaging of human breast tumors. Nat. Med. 20, 436–442 (2014).
doi: 10.1038/nm.3488 pubmed: 24584119 pmcid: 4110905
Gerdes, M. J. et al. Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue. Proc. Natl Acad. Sci. USA 110, 11982–11987 (2013).
doi: 10.1073/pnas.1300136110 pubmed: 23818604 pmcid: 3718135
Schapiro, D. et al. histoCAT: analysis of cell phenotypes and interactions in multiplex image cytometry data. Nat. Methods 14, 873–876 (2017).
doi: 10.1038/nmeth.4391 pubmed: 28783155 pmcid: 5617107
Keren, L. et al. A structured tumor-immune microenvironment in triple negative breast cancer revealed by multiplexed ion beam imaging. Cell 174, 1373–1387 (2018).
doi: 10.1016/j.cell.2018.08.039 pubmed: 30193111 pmcid: 6132072
Carvajal-Hausdorf, D. E. et al. Multiplexed (18-plex) measurement of signaling targets and cytotoxic T cells in trastuzumab-treated patients using imaging mass cytometry. Clin. Cancer Res. 25, 3054–3062 (2019).
doi: 10.1158/1078-0432.CCR-18-2599 pubmed: 30796036 pmcid: 6522272
Damond, N. et al. A map of human type 1 diabetes progression by imaging mass cytometry. Cell Metab. 29, 755–768 (2019).
doi: 10.1016/j.cmet.2018.11.014 pubmed: 30713109 pmcid: 6821395
Bodenmiller, B. Multiplexed epitope-based tissue imaging for discovery and healthcare applications. Cell Syst. 2, 225–238 (2016).
doi: 10.1016/j.cels.2016.03.008 pubmed: 27135535
Lin, J.-R. et al. Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes. eLife7, e31657 (2018).
Levine, J. H. et al. Data-driven phenotypic dissection of AML reveals progenitor-like cells that correlate with prognosis. Cell 162, 184–197 (2015).
doi: 10.1016/j.cell.2015.05.047 pubmed: 26095251 pmcid: 4508757
Blondel, V. D., Guillaume, J.-L., Lambiotte, R. & Lefebvre, E. Fast unfolding of communities in large networks. J. Stat. Mech. 2008, P10008 (2008).
doi: 10.1088/1742-5468/2008/10/P10008
Kalluri, R. The biology and function of fibroblasts in cancer. Nat. Rev. Cancer 16, 582–598 (2016).
doi: 10.1038/nrc.2016.73 pubmed: 27550820
Kononen, J. et al. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat. Med. 4, 844–847 (1998).
doi: 10.1038/nm0798-844 pubmed: 9662379
Kündig, P. et al. Limited utility of tissue micro-arrays in detecting intra-tumoral heterogeneity in stem cell characteristics and tumor progression markers in breast cancer. J. Transl. Med. 16, 118 (2018).
doi: 10.1186/s12967-018-1495-6 pubmed: 29739401 pmcid: 5941467
Chevrier, S. et al. Compensation of signal spillover in suspension and imaging mass cytometry. Cell Syst. 6, 612–620 (2018).
doi: 10.1016/j.cels.2018.02.010 pubmed: 29605184 pmcid: 5981006
Sommer, C., Straehle, C., Köthe, U. & Hamprecht, F. A. Ilastic: interactive learning and segmentation toolkit. In Proc. 2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro 230–233 (IEEE, 2011).
Carpenter, A. E. et al. CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol. 7, R100 (2006).
doi: 10.1186/gb-2006-7-10-r100 pubmed: 17076895 pmcid: 1794559
Amir, A. D. et al. viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia. Nat. Biotechnol. 31, 545–552 (2013).
doi: 10.1038/nbt.2594 pubmed: 23685480 pmcid: 4076922
Angel Martín, M., & Rey, J.-M. (2000). On the role of Shannon’s entropy as a measure of heterogeneity. Geoderma 98, 1–3 (2000).
doi: 10.1016/S0016-7061(00)00049-5
Kullback, S. & Leibler, R. A. On information and sufficiency. Ann. Math. Stat. 22, 79–86 (1951).
doi: 10.1214/aoms/1177729694
Expert, P., Evans, T. S., Blondel, V. D. & Lambiotte, R. Uncovering space-independent communities in spatial networks. Proc. Natl Acad. Sci. USA, 108, 7663–7668 (2011).
doi: 10.1073/pnas.1018962108 pubmed: 21518910 pmcid: 3093492

Auteurs

Hartland W Jackson (HW)

Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.
Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.

Jana R Fischer (JR)

Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.
Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
Life Science Zurich Graduate School, ETH Zurich and University of Zurich, Zurich, Switzerland.

Vito R T Zanotelli (VRT)

Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.
Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
Life Science Zurich Graduate School, ETH Zurich and University of Zurich, Zurich, Switzerland.

H Raza Ali (HR)

Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.
Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.

Robert Mechera (R)

Department of Surgery, University of Basel and University Hospital Basel, Basel, Switzerland.

Savas D Soysal (SD)

Department of Biomedicine, University of Basel, Basel, Switzerland.
Visceral Surgery Research Laboratory, Department of Surgery, Clarunis University Center for Gastrointestinal and Liver Diseases Basel, Basel, Switzerland.

Holger Moch (H)

Institute of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.

Simone Muenst (S)

Institute of Pathology and Genetics, University Hospital Basel, Basel, Switzerland.

Zsuzsanna Varga (Z)

Institute of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.

Walter P Weber (WP)

Department of Surgery, University of Basel and University Hospital Basel, Basel, Switzerland.

Bernd Bodenmiller (B)

Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland. bernd.bodenmiller@uzh.ch.
Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland. bernd.bodenmiller@uzh.ch.

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