Antibody Targeted PET Imaging of


Journal

Bioconjugate chemistry
ISSN: 1520-4812
Titre abrégé: Bioconjug Chem
Pays: United States
ID NLM: 9010319

Informations de publication

Date de publication:
18 03 2020
Historique:
pubmed: 22 1 2020
medline: 12 2 2021
entrez: 22 1 2020
Statut: ppublish

Résumé

Lipid nanodiscs (LNDs), comprising a phospholipid bilayer encircled by two molecules of a recombinant membrane scaffold protein, can be targeted to tumors with covalently attached antibodies (Abs) or their fragments. Antibody attachment to click chemistry based PEGylated lipids on LNDs including DOTA allowed PET imaging with the positron emitter

Identifiants

pubmed: 31961138
doi: 10.1021/acs.bioconjchem.9b00854
pmc: PMC8818266
mid: NIHMS1772722
doi:

Substances chimiques

Azides 0
Carcinoembryonic Antigen 0
Copper Radioisotopes 0
Copper-64 0
Heterocyclic Compounds, 1-Ring 0
Immunoconjugates 0
Phospholipids 0
1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid 1HTE449DGZ
Polyethylene Glycols 3WJQ0SDW1A

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

743-753

Subventions

Organisme : NCI NIH HHS
ID : P30 CA033572
Pays : United States

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Auteurs

Patty Wong (P)

Department of Radiation Oncology, City of Hope Medical Center, Duarte, California 91010, United States.

Lin Li (L)

Department of Molecular Imaging and Therapy, Beckman Research Institute, City of Hope, Duarte, California 91010, United States.

Junie Chea (J)

Radiopharmacy, City of Hope Medical Center, Duarte, California 91010, United States.

Weidong Hu (W)

Department of Molecular Imaging and Therapy, Beckman Research Institute, City of Hope, Duarte, California 91010, United States.

Erasmus Poku (E)

Radiopharmacy, City of Hope Medical Center, Duarte, California 91010, United States.

Todd Ebner (T)

Department of Molecular Imaging and Therapy, Beckman Research Institute, City of Hope, Duarte, California 91010, United States.

Nicole Bowles (N)

Radiopharmacy, City of Hope Medical Center, Duarte, California 91010, United States.

Jeffrey Y C Wong (JYC)

Department of Radiation Oncology, City of Hope Medical Center, Duarte, California 91010, United States.

Paul J Yazaki (PJ)

Department of Molecular Imaging and Therapy, Beckman Research Institute, City of Hope, Duarte, California 91010, United States.

Stephen Sligar (S)

Department of Molecular and Cellular Biology, University of Illinois, Urbana, Illinois 61801, United States.

John E Shively (JE)

Department of Molecular Imaging and Therapy, Beckman Research Institute, City of Hope, Duarte, California 91010, United States.

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Classifications MeSH