Cell junction proteins: Crossing the glomerular filtration barrier in diabetic nephropathy.
Animals
Cell Adhesion Molecules
/ metabolism
Cell Communication
Diabetic Nephropathies
/ etiology
Disease Susceptibility
Endothelial Cells
/ metabolism
Gap Junctions
/ metabolism
Glomerular Filtration Barrier
/ metabolism
Humans
Intercellular Junctions
/ metabolism
Membrane Proteins
/ metabolism
Podocytes
/ metabolism
Diabetic nephropathy
Gap junctions
Podocytes
Proteinuria
Slit diagrams
Tight junctions
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
01 Apr 2020
01 Apr 2020
Historique:
received:
15
10
2019
revised:
17
01
2020
accepted:
17
01
2020
pubmed:
22
1
2020
medline:
2
12
2020
entrez:
22
1
2020
Statut:
ppublish
Résumé
Diabetic nephropathy as a deleterious complication of diabetes mellitus and an important cause of end-stage renal failure is characterized by changes in the molecular and cellular levels. Cell-cell communication via the gap and tight junctions are involved in the pathogenesis of diseases such as diabetes and kidney failure. Studying cell junctions including gap junctions, tight junctions, and anchoring junctions within the nephron can be used as an early sign of diabetic nephropathy. Furthermore, cell junctions may be an upcoming target by pharmacological methods to improve treatments of diabetic nephropathy and pave the way to introduce promising therapeutic strategies based on cell-cell communications effects and its translation into clinical studies for the treatment of diabetic nephropathy.
Identifiants
pubmed: 31962072
pii: S0141-8130(19)38364-3
doi: 10.1016/j.ijbiomac.2020.01.168
pii:
doi:
Substances chimiques
Cell Adhesion Molecules
0
Membrane Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
475-482Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest None.