Detrimental Role of Nerve Injury-Induced Protein 1 in Myeloid Cells under Intestinal Inflammatory Conditions.
Animals
Cell Adhesion
Cell Adhesion Molecules, Neuronal
/ physiology
Cell Movement
Cells, Cultured
Colitis
/ etiology
Female
Inflammation
/ etiology
Intestinal Diseases
/ etiology
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Myeloid Cells
/ metabolism
Nerve Growth Factors
/ physiology
Signal Transduction
IBD
IL1β
Ninjurin1
inflammation
myeloid cells
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Jan 2020
17 Jan 2020
Historique:
received:
15
12
2019
revised:
15
01
2020
accepted:
16
01
2020
entrez:
23
1
2020
pubmed:
23
1
2020
medline:
24
10
2020
Statut:
epublish
Résumé
Nerve injury-induced protein 1 (Ninjurin1, Ninj1) is a cell-surface adhesion molecule that regulates cell migration and attachment. This study demonstrates the increase in Ninj1 protein expression during development of intestinal inflammation. Ninj1-deficient mice exhibited significantly attenuated bodyweight loss, shortening of colon length, intestinal inflammation, and lesser pathological lesions than wild-type mice. Although more severe inflammation and serious lesions are observed in wild-type mice than Ninj1-deficient mice, there were no changes in the numbers of infiltrating macrophages in the inflamed tissues obtained from WT and Ninj1-deficient mice. Ninj1 expression results in activation of macrophages, and these activated macrophages secrete more cytokines and chemokines than Ninj1-deficient macrophages. Moreover, mice with conditional deletion of Ninj1 in myeloid cells (Ninj1
Identifiants
pubmed: 31963519
pii: ijms21020614
doi: 10.3390/ijms21020614
pmc: PMC7013940
pii:
doi:
Substances chimiques
Cell Adhesion Molecules, Neuronal
0
Nerve Growth Factors
0
Ninj1 protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Science, ICT and Future Planning
ID : NRF-2019M3A9D5A01101025
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