Transcriptome Modifications in the Porcine Intramuscular Adipocytes during Differentiation and Exogenous Stimulation with TNF-α and Serotonin.
Adipocytes
/ cytology
Animals
Cell Differentiation
/ drug effects
Cells, Cultured
Dose-Response Relationship, Drug
Female
Gene Expression Profiling
/ veterinary
Gene Expression Regulation
/ drug effects
Gene Regulatory Networks
/ drug effects
Lipid Metabolism
/ drug effects
Muscle, Skeletal
/ cytology
Serotonin
/ pharmacology
Swine
Tumor Necrosis Factor-alpha
/ pharmacology
TNF-α
adipogenesis
porcine intramuscular preadipocyte (PIP)
porcine mature adipocyte (pMA)
serotonin
serotonin receptor
transcriptome
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
18 Jan 2020
18 Jan 2020
Historique:
received:
23
12
2019
revised:
15
01
2020
accepted:
16
01
2020
entrez:
23
1
2020
pubmed:
23
1
2020
medline:
9
10
2020
Statut:
epublish
Résumé
Adipocytes are dynamic cells that have critical functions to maintain body energy homeostasis. Adipocyte physiology is affected by the adipogenic differentiation, cell program, as well as by the exogenous stimulation of biochemical factors, such as serotonin and TNF-α. In this work, we investigated the global transcriptome modifications when porcine intramuscular preadipocyte (PIP) was differentiated into porcine mature adipocyte (pMA). Moreover, we studied transcriptome changes in pMA after stimulation with serotonin or TNF-α by using a microarray approach. Transcriptome analysis revealed that the expression of 270, 261, and 249 genes were modified after differentiation, or after serotonin and TNF-α stimulation, respectively. Expression changes in
Identifiants
pubmed: 31963662
pii: ijms21020638
doi: 10.3390/ijms21020638
pmc: PMC7013444
pii:
doi:
Substances chimiques
Tumor Necrosis Factor-alpha
0
Serotonin
333DO1RDJY
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : 16H06429, 16K21723, and 16H06435
Organisme : Japan Society for the Promotion of Science
ID : (A) (19H00965); (B) (16H05019); (26660216, 16K15028); 18F18081 and 15F15401
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