Microencapsulated Tuna Oil Results in Higher Absorption of DHA in Toddlers.
Age Factors
Animals
Biological Availability
Child Behavior
Child Nutritional Physiological Phenomena
Child, Preschool
Crying
Dietary Supplements
Docosahexaenoic Acids
/ administration & dosage
Female
Habits
Humans
Infant
Infant Behavior
Infant Formula
Infant Nutritional Physiological Phenomena
Intestinal Absorption
Malaysia
Male
Nutritional Status
Powders
Sleep
Tuna
DHA
bioavailability
microencapsulation
omega-3
toddlers
tuna oil
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
18 Jan 2020
18 Jan 2020
Historique:
received:
29
11
2019
revised:
15
01
2020
accepted:
15
01
2020
entrez:
23
1
2020
pubmed:
23
1
2020
medline:
20
11
2020
Statut:
epublish
Résumé
: Docosahexaenoic acid (DHA) is an essential component for brain and visual acuity development during foetal and early postnatal life. A newly released directive under the European Commission stipulates DHA as a mandatory ingredient in infant formula. This poses challenges to manufacturers in preserving the stability and bioavailability of DHA at levels akin to human breast milk. The aims of this study were (a) to investigate the bioavailability of microencapsulated omega-3 DHA formulations in healthy toddlers compared with high DHA fish oil for a one-month period and (b) to assess the effect of DHA supplementation on children's sleep and cry patterns. Sixty toddlers were randomly allocated to four groups: 1. unfortified formula, 2. unfortified formula plus high DHA tuna oil, 3. fortified formula with dairy-based microencapsulated high DHA tuna oil powder, and 4. fortified formula with allergenic-free microencapsulated high DHA tuna oil powder. Bioavailability was assessed from both blood and faecal fatty acid levels. The results showed an enhanced bioavailability with significantly greater concentrations of blood DHA levels in formulas with microencapsulated powders. There were no significant effects of treatment on sleep and cry patterns. Application and delivery of microencapsulated DHA tuna oil powder in toddlers' formula provided better bioavailability of the active DHA.
Identifiants
pubmed: 31963702
pii: nu12010248
doi: 10.3390/nu12010248
pmc: PMC7019307
pii:
doi:
Substances chimiques
Powders
0
Docosahexaenoic Acids
25167-62-8
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors, SGF and GE are employees of Nu-Mega Ingredients Pty Ltd., a manufacturer and supplier of high DHA fish oil products. While Nu-Mega Ingredients Pty Ltd. provided support in the form of salaries for authors S.G.F and G.E, and funded the study, they did not have any role in the blood and faeces fatty acid analyses.
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