Essential Amino Acid Supplement Lowers Intrahepatic Lipid despite Excess Alcohol Consumption.
Adult
Alaska
Alcohol Drinking
/ adverse effects
Amino Acids, Essential
/ administration & dosage
Biomarkers
/ blood
Body Composition
/ drug effects
Dietary Supplements
/ adverse effects
Fatty Liver, Alcoholic
/ drug therapy
Female
Humans
Lipids
/ blood
Liver
/ drug effects
Male
Middle Aged
Pilot Projects
Time Factors
Treatment Outcome
Young Adult
alcohol
amino acids
liver
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
19 Jan 2020
19 Jan 2020
Historique:
received:
16
12
2019
revised:
07
01
2020
accepted:
09
01
2020
entrez:
23
1
2020
pubmed:
23
1
2020
medline:
20
11
2020
Statut:
epublish
Résumé
Excess alcohol consumption is a top risk factor for death and disability. Fatty liver will likely develop and the risk of liver disease increases. We have previously demonstrated that an essential amino acid supplement (EAAS) improved protein synthesis and reduced intrahepatic lipid in the elderly. The purpose of this exploratory pilot study was to initiate the evaluation of EAAS on intrahepatic lipid (IHL), body composition, and blood lipids in individuals with mild to moderate alcohol use disorder (AUD). Following consent, determination of eligibility, and medical screening, 25 participants (18 males at 38 ± 15 years/age and 7 females at 34 ± 18 years/age) were enrolled and randomly assigned to one of two dosages: a low dose (LD: 8 g of EAAS twice/day (BID)) or high dose (HD: 13 g of EAAS BID). Five of the twenty-five enrolled participants dropped out of the intervention. Both groups consumed the supplement BID for 4 weeks. Pre- and post-EAAS administration, IHL was determined using magnetic resonance imaging/spectroscopy, body composition was analyzed using dual-energy X-ray absorptiometry, and blood parameters were measured by LabCorp. T-tests were used for statistical analysis and considered significant at
Identifiants
pubmed: 31963802
pii: nu12010254
doi: 10.3390/nu12010254
pmc: PMC7019240
pii:
doi:
Substances chimiques
Amino Acids, Essential
0
Biomarkers
0
Lipids
0
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : TL4 GM118992
Pays : United States
Organisme : NIGMS NIH HHS
ID : UL1 GM118991
Pays : United States
Organisme : NIGMS NIH HHS
ID : RL5 GM118990
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM130443
Pays : United States
Organisme : NIH HHS
ID : P20GM103395
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103395
Pays : United States
Organisme : NIGMS NIH HHS
ID : T34 GM141009
Pays : United States
Organisme : NIH HHS
ID : UL1GM118991
Pays : United States
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