MicroRNAs in Vascular Eye Diseases.
AMD: biomarker
eye disease
microRNA
neovascularization
retinopathy
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Jan 2020
19 Jan 2020
Historique:
received:
27
12
2019
accepted:
16
01
2020
entrez:
23
1
2020
pubmed:
23
1
2020
medline:
8
10
2020
Statut:
epublish
Résumé
Since the discovery of the first microRNA (miRNA) decades ago, studies of miRNA biology have expanded in many biomedical research fields, including eye research. The critical roles of miRNAs in normal development and diseases have made miRNAs useful biomarkers or molecular targets for potential therapeutics. In the eye, ocular neovascularization (NV) is a leading cause of blindness in multiple vascular eye diseases. Current anti-angiogenic therapies, such as anti-vascular endothelial growth factor (VEGF) treatment, have their limitations, indicating the need for investigating new targets. Recent studies established the roles of various miRNAs in the regulation of pathological ocular NV, suggesting miRNAs as both biomarkers and therapeutic targets in vascular eye diseases. This review summarizes the biogenesis of miRNAs, and their functions in the normal development and diseases of the eye, with a focus on clinical and experimental retinopathies in both human and animal models. Discovery of novel targets involving miRNAs in vascular eye diseases will provide insights for developing new treatments to counter ocular NV.
Identifiants
pubmed: 31963809
pii: ijms21020649
doi: 10.3390/ijms21020649
pmc: PMC7014392
pii:
doi:
Substances chimiques
Angiogenesis Inhibitors
0
Genetic Markers
0
MicroRNAs
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NEI NIH HHS
ID : R01 EY024963
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY028100
Pays : United States
Organisme : NIH HHS
ID : EY028100; EY024963
Pays : United States
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