Population Pharmacokinetic Study of the Suitability of Standard Dosing Regimens of Amikacin in Critically Ill Patients with Open-Abdomen and Negative-Pressure Wound Therapy.
Aged
Amikacin
/ pharmacokinetics
Anti-Bacterial Agents
/ pharmacokinetics
Bacteria
/ drug effects
Critical Illness
/ therapy
Female
Humans
Intra-Abdominal Hypertension
/ prevention & control
Male
Microbial Sensitivity Tests
Middle Aged
Monte Carlo Method
Negative-Pressure Wound Therapy
/ methods
Open Abdomen Techniques
/ adverse effects
Sepsis
/ drug therapy
Wounds and Injuries
/ therapy
Monte Carlo simulation
amikacin
intensive care
negative-pressure therapy
open abdomen
pharmacokinetics
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
24 03 2020
24 03 2020
Historique:
received:
17
10
2019
accepted:
07
01
2020
pubmed:
23
1
2020
medline:
29
1
2021
entrez:
23
1
2020
Statut:
epublish
Résumé
The aim was to assess the appropriateness of recommended regimens for empirical MIC coverage in critically ill patients with open-abdomen and negative-pressure therapy (OA/NPT). Over a 5-year period, every critically ill patient who received amikacin and who underwent therapeutic drug monitoring (TDM) while being treated by OA/NPT was retrospectively included. A population pharmacokinetic (PK) modeling was performed considering the effect of 10 covariates (age, sex, total body weight [TBW], adapted body weight [ABW], body surface area [BSA], modified sepsis-related organ failure assessment [SOFA] score, vasopressor use, creatinine clearance [CL
Identifiants
pubmed: 31964795
pii: AAC.02098-19
doi: 10.1128/AAC.02098-19
pmc: PMC7179257
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Amikacin
84319SGC3C
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 American Society for Microbiology.
Références
Int J Antimicrob Agents. 2018 Apr;51(4):562-570
pubmed: 29180278
Eur J Drug Metab Pharmacokinet. 1999 Jan-Mar;24(1):39-46
pubmed: 10412890
Ann Intensive Care. 2016 Dec;6(1):106
pubmed: 27807818
Antimicrob Agents Chemother. 2019 Feb 26;63(3):
pubmed: 30602511
Int J Antimicrob Agents. 2011 Jun;37(6):531-5
pubmed: 21489756
Clin Ther. 2004 Feb;26(2):271-81
pubmed: 15038949
Eur J Clin Pharmacol. 2015 Jan;71(1):75-83
pubmed: 25327505
Intensive Care Med. 2014 Jul;40(7):998-1005
pubmed: 24687298
J Infect Dis. 1987 Jan;155(1):93-9
pubmed: 3540140
Ther Drug Monit. 2010 Dec;32(6):749-56
pubmed: 20962708
Int J Surg. 2014 Oct;12(10):1105-14
pubmed: 25174789
J Glob Antimicrob Resist. 2018 Mar;12:90-95
pubmed: 29017888
Antimicrob Agents Chemother. 2016 Jul 22;60(8):4901-9
pubmed: 27270279
Antimicrob Agents Chemother. 2019 Oct 22;63(11):
pubmed: 31481443
Crit Care. 2011 Jun 08;15(3):R139
pubmed: 21651804
Crit Care Med. 1997 May;25(5):806-11
pubmed: 9187600
Crit Care. 2018 Jul 23;22(1):177
pubmed: 30037335
Anaesth Crit Care Pain Med. 2018 Feb;37(1):35-41
pubmed: 28756331
Int J Antimicrob Agents. 2015 Jul;46(1):21-7
pubmed: 25857948
Anaesthesiol Intensive Ther. 2015;47(4):372-8
pubmed: 25973658
J Antimicrob Chemother. 2015 May;70(5):1495-502
pubmed: 25608584
Clin Infect Dis. 2007 Sep 15;45(6):753-60
pubmed: 17712761
Med Mal Infect. 2012 Jul;42(7):301-8
pubmed: 22770656
J Antimicrob Chemother. 1999 Jul;44(1):99-108
pubmed: 10459816
J Antimicrob Chemother. 2016 Jan;71(1):208-12
pubmed: 26429564
Clin Drug Investig. 1998;15(5):435-44
pubmed: 18370499
Int J Antimicrob Agents. 2013 Aug;42(2):155-60
pubmed: 23756322
Antimicrob Agents Chemother. 1996 Jul;40(7):1682-9
pubmed: 8807062
Crit Care. 2010;14(2):R53
pubmed: 20370907
Antimicrob Agents Chemother. 1999 Mar;43(3):623-9
pubmed: 10049277
Fundam Clin Pharmacol. 1995;9(1):57-61
pubmed: 7768489
Pharmacotherapy. 2018 Dec;38(12):1229-1238
pubmed: 30403305
Infect Dis Ther. 2013 Dec;2(2):217-26
pubmed: 25134484
Crit Care. 2013 Jul 25;17(4):R165
pubmed: 23886243
Clin Pharmacokinet. 2017 Feb;56(2):127-138
pubmed: 27324191