Lactobacilli modulated AMPK activity and prevented telomere shortening in ageing rats.
AMP-Activated Protein Kinases
/ genetics
Aging, Premature
/ chemically induced
Animals
Diet, High-Fat
/ adverse effects
Disease Models, Animal
Galactose
/ administration & dosage
Gene Expression
/ drug effects
Lactobacillus
/ physiology
Lipid Peroxidation
/ drug effects
Male
Physical Endurance
/ drug effects
Probiotics
/ administration & dosage
Rats
Rats, Sprague-Dawley
Telomere Shortening
/ drug effects
Lactobacillus
brain
impairment
muscle
telomere
Journal
Beneficial microbes
ISSN: 1876-2891
Titre abrégé: Benef Microbes
Pays: Netherlands
ID NLM: 101507616
Informations de publication
Date de publication:
09 Dec 2019
09 Dec 2019
Historique:
entrez:
23
1
2020
pubmed:
23
1
2020
medline:
19
5
2020
Statut:
ppublish
Résumé
This study aimed to evaluate the anti-ageing effects of different strains of lactobacilli putative probiotics on an ageing rat model as induced by D-galactose and a high fat diet. Male Sprague-Dawley rats were fed with high fat diet (54% kcal fat) and injected with D-galactose daily for 12 weeks to induce ageing. The effects of putative probiotic strains on age-related impairment such as telomere length, plasma lipid peroxidation, hepatic 5'adenosine monophosphate-activated protein kinase (AMPK) expression, as well as endurance performance were evaluated. Administration of statin,
Substances chimiques
AMP-Activated Protein Kinases
EC 2.7.11.31
Galactose
X2RN3Q8DNE
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM