Human Liver Memory CD8
IL-15
T cell
autophagy
hepatitis B virus
immunometabolism
liver
mitophagy
tissue-resident
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
21 01 2020
21 01 2020
Historique:
received:
08
08
2019
revised:
04
11
2019
accepted:
13
12
2019
entrez:
23
1
2020
pubmed:
23
1
2020
medline:
18
3
2021
Statut:
ppublish
Résumé
Tissue-resident memory T cells have critical roles in long-term pathogen and tumor immune surveillance in the liver. We investigate the role of autophagy in equipping human memory T cells to acquire tissue residence and maintain functionality in the immunosuppressive liver environment. By performing ex vivo staining of freshly isolated cells from human liver tissue, we find that an increased rate of basal autophagy is a hallmark of intrahepatic lymphocytes, particularly liver-resident CD8
Identifiants
pubmed: 31968246
pii: S2211-1247(19)31707-3
doi: 10.1016/j.celrep.2019.12.050
pmc: PMC6988113
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
687-698.e6Subventions
Organisme : Cancer Research UK
ID : 26813
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0901374
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 101849/Z/13/A
Pays : United Kingdom
Organisme : MRF
ID : MRF_MRF-044-0001-RG-SWADL
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests Authors declare no competing interests. The Maini Laboratory has received unrestricted research grants from Gilead Science Inc, Roche, and Immunocore.
Références
Autophagy. 2012 Apr;8(4):677-89
pubmed: 22302009
Eur J Immunol. 2014 Aug;44(8):2508-20
pubmed: 24796540
Cell Rep. 2016 Aug 2;16(5):1243-1252
pubmed: 27452473
Trends Cell Biol. 2013 Jul;23(7):311-8
pubmed: 23489877
J Biol Chem. 2015 May 1;290(18):11376-83
pubmed: 25833948
Autophagy. 2009 Jul;5(5):625-35
pubmed: 19276668
Lancet Gastroenterol Hepatol. 2018 Mar;3(3):192-202
pubmed: 29870733
J Immunol. 2015 May 1;194(9):4277-86
pubmed: 25833396
J Virol. 2016 Sep 12;90(19):8563-74
pubmed: 27440883
J Biol Chem. 2010 Apr 2;285(14):10850-61
pubmed: 20123989
J Immunol. 2010 Dec 15;185(12):7349-57
pubmed: 21059894
Hepatology. 2017 Jul;66(1):57-68
pubmed: 28295463
Cell Rep. 2018 Jul 31;24(5):1136-1150
pubmed: 30067971
J Exp Med. 2008 Sep 1;205(9):2111-24
pubmed: 18695005
Cancer Res. 2015 Dec 15;75(24):5187-5193
pubmed: 26627006
J Immunol. 2009 Apr 1;182(7):4046-55
pubmed: 19299702
J Exp Med. 2013 Sep 23;210(10):2119-34
pubmed: 24043759
Trends Cell Biol. 2018 Nov;28(11):882-895
pubmed: 30115557
Hepatol Commun. 2018 Oct 30;2(12):1425-1439
pubmed: 30556032
J Exp Med. 2007 Jan 22;204(1):25-31
pubmed: 17190837
J Immunol. 2017 Oct 1;199(7):2536-2546
pubmed: 28814601
Nature. 1999 Oct 14;401(6754):708-12
pubmed: 10537110
Nat Commun. 2018 Jul 18;9(1):2812
pubmed: 30022064
Sci Rep. 2018 Apr 13;8(1):5951
pubmed: 29654322
Gastroenterology. 2012 Apr;142(4):938-46
pubmed: 22240484
Elife. 2014 Nov 11;3:null
pubmed: 25385531
Immunity. 2016 Aug 16;45(2):358-73
pubmed: 27496729
JCI Insight. 2018 Nov 15;3(22):
pubmed: 30429372
Immunol Cell Biol. 2018 Jul;96(6):666-674
pubmed: 29423939
Cold Spring Harb Protoc. 2015 Sep 01;2015(9):pdb.prot086298
pubmed: 26330624
Immunity. 2007 Jan;26(1):117-29
pubmed: 17239632
Cell Mol Gastroenterol Hepatol. 2018 Jan 08;5(3):399-413
pubmed: 29552626
J Exp Med. 2018 Feb 5;215(2):399-413
pubmed: 29326381
Autophagy. 2016;12(1):1-222
pubmed: 26799652
Clin Exp Immunol. 2004 Oct;138(1):94-101
pubmed: 15373910
J Hepatol. 2016 Aug;65(2):344-353
pubmed: 27154062
J Immunol. 2011 May 1;186(9):5313-22
pubmed: 21421856
J Exp Med. 2019 Jan 7;216(1):133-151
pubmed: 30518599
J Cell Mol Med. 2011 Jun;15(6):1239-53
pubmed: 21251211
Cell Rep. 2018 Oct 2;25(1):68-79.e4
pubmed: 30282039
Immunity. 2015 Dec 15;43(6):1101-11
pubmed: 26682984
Autophagy. 2018;14(2):199-206
pubmed: 28806133
Nat Rev Immunol. 2019 Mar;19(3):170-183
pubmed: 30531943
Nature. 2018 Dec;564(7734):24-26
pubmed: 30518904
Cell Rep. 2019 Apr 9;27(2):502-513.e5
pubmed: 30970253
Elife. 2016 Feb 24;5:e12444
pubmed: 26910010
Ann Rheum Dis. 2015 May;74(5):912-20
pubmed: 24419333
Mem Inst Oswaldo Cruz. 2011 Aug;106 Suppl 1:172-8
pubmed: 21881772
Nat Med. 2015 Jun;21(6):591-600
pubmed: 25962123
Autophagy. 2010 Jul;6(5):634-41
pubmed: 20458170
Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7788-E7797
pubmed: 27849617
J Hepatol. 2015 Feb;62(2):486-91
pubmed: 25308176
Aging Cell. 2017 Dec;16(6):1234-1243
pubmed: 28834142
Immunity. 2016 Oct 18;45(4):889-902
pubmed: 27692609
Autophagy. 2015;11(10):1864-77
pubmed: 26391567
Nat Immunol. 2014 Dec;15(12):1152-61
pubmed: 25362489
J Exp Med. 2017 Jun 5;214(6):1567-1580
pubmed: 28526759
J Immunol. 2017 Feb 1;198(3):1172-1182
pubmed: 28031333
Cell Rep. 2016 May 31;15(9):1910-9
pubmed: 27210760
J Exp Med. 2005 Jan 3;201(1):139-48
pubmed: 15630141
Nat Rev Immunol. 2012 Feb 24;12(3):201-13
pubmed: 22362353
PLoS Pathog. 2018 Apr 13;14(4):e1006993
pubmed: 29652930
Lancet. 2018 Nov 10;392(10159):2052-2090
pubmed: 30340847
Nat Med. 2017 Mar;23(3):327-336
pubmed: 28165481