Anti-Oxidant and digestive enzymes inhibitory based anti diabetic activity of crude and fractions of Carum carvi L. extracts.
Antioxidants
/ isolation & purification
Carum
/ chemistry
Dose-Response Relationship, Drug
Gas Chromatography-Mass Spectrometry
Glycoside Hydrolase Inhibitors
/ isolation & purification
Humans
Hypoglycemic Agents
/ isolation & purification
Phytotherapy
Plant Extracts
/ isolation & purification
Seeds
/ chemistry
alpha-Amylases
/ antagonists & inhibitors
alpha-Glucosidases
/ drug effects
Journal
Pakistan journal of pharmaceutical sciences
ISSN: 1011-601X
Titre abrégé: Pak J Pharm Sci
Pays: Pakistan
ID NLM: 9426356
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
entrez:
24
1
2020
pubmed:
24
1
2020
medline:
14
8
2020
Statut:
ppublish
Résumé
In the present study crude ethanolic extract and its various fractions (ethyl acetate, hexane and aqueous) of medicinal plant Carum carvi L. were examined for α-amylase and α-glucosidase inhibition using an-in vitro model. Both digestive enzymes were extracted from bovine and green gram. The crude extract and its fractions were also studied for their antioxidant potential by DPPH and Nitric oxide activity. The quantitative assessment of phenol and flavonoid contents was also estimated. The crude extract and its fractions exhibited high in-vitro enzyme inhibitory activity against α-amylase and α-glucosidase at different concentrations with IC
Substances chimiques
Antioxidants
0
Glycoside Hydrolase Inhibitors
0
Hypoglycemic Agents
0
Plant Extracts
0
alpha-Amylases
EC 3.2.1.1
alpha-Glucosidases
EC 3.2.1.20
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM