TRPV4 Protects the Lung from Bacterial Pneumonia via MAPK Molecular Pathway Switching.
Animals
Female
Humans
Inflammation
/ genetics
Lipopolysaccharides
/ immunology
Lung
/ immunology
MAP Kinase Signaling System
/ genetics
Macrophage Activation
Macrophages
/ immunology
Mice
Mice, Mutant Strains
Mitogen-Activated Protein Kinase Kinases
/ genetics
Pneumonia, Bacterial
/ genetics
Pseudomonas Infections
/ genetics
Pseudomonas aeruginosa
/ immunology
TRPV Cation Channels
/ genetics
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 03 2020
01 03 2020
Historique:
received:
23
08
2019
accepted:
22
12
2019
pubmed:
24
1
2020
medline:
9
9
2020
entrez:
24
1
2020
Statut:
ppublish
Résumé
Mechanical cell-matrix interactions can drive the innate immune responses to infection; however, the molecular underpinnings of these responses remain elusive. This study was undertaken to understand the molecular mechanism by which the mechanosensitive cation channel, transient receptor potential vanilloid 4 (TRPV4), alters the in vivo response to lung infection. For the first time, to our knowledge, we show that TRPV4 protects the lung from injury upon intratracheal
Identifiants
pubmed: 31969384
pii: jimmunol.1901033
doi: 10.4049/jimmunol.1901033
pmc: PMC7033031
mid: NIHMS1547579
doi:
Substances chimiques
Lipopolysaccharides
0
TRPV Cation Channels
0
TRPV4 protein, human
0
Trpv4 protein, mouse
0
Mitogen-Activated Protein Kinase Kinases
EC 2.7.12.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1310-1321Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR002548
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000439
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL132079
Pays : United States
Organisme : NIH HHS
ID : S10 OD019972
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133721
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL119792
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL133380
Pays : United States
Informations de copyright
Copyright © 2020 by The American Association of Immunologists, Inc.
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