Inhibition of SREBP Improves Cardiac Lipidopathy, Improves Endoplasmic Reticulum Stress, and Modulates Chronic Chagas Cardiomyopathy.

Animals Cell Line Chagas Cardiomyopathy / drug therapy Chronic Disease Disease Models, Animal Endoplasmic Reticulum Stress / drug effects Host-Parasite Interactions Lipid Metabolism / drug effects Male Mice, Inbred C3H Myocytes, Cardiac / drug effects Rats Sterol Regulatory Element Binding Proteins / antagonists & inhibitors Triterpenes / pharmacology Trypanosoma cruzi / pathogenicity
Chagas disease SREBP activation betulin cardiomyopathy endoplasmic reticulum stress mitochondrial stress

Journal

Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524

Informations de publication

Date de publication:
04 02 2020
Historique:
entrez: 25 1 2020
pubmed: 25 1 2020
medline: 22 12 2020
Statut: ppublish

Résumé

Background

Identifiants

DOI: 10.1161/JAHA.119.014255 PMID: 31973605 PMC: PMC7033903
pubmed: 31973605
doi: 10.1161/JAHA.119.014255
pmc: PMC7033903
doi:

Substances chimiques

Sterol Regulatory Element Binding Proteins 0
Triterpenes 0
betulin 6W70HN7X7O

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e014255

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL122866
Pays : United States

Références

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Auteurs

Janeesh Plakkal Ayyappan (JP)

Department of Microbiology, Biochemistry and Molecular Genetics Public Health Research Institute New Jersey Medical School Newark NY.

Kezia Lizardo (K)

Department of Microbiology, Biochemistry and Molecular Genetics Public Health Research Institute New Jersey Medical School Newark NY.

Sean Wang (S)

Rutgers Molecular Imaging Center Piscataway NJ.

Edward Yurkow (E)

Rutgers Molecular Imaging Center Piscataway NJ.

Jyothi F Nagajyothi (JF)

Department of Microbiology, Biochemistry and Molecular Genetics Public Health Research Institute New Jersey Medical School Newark NY.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Inhibition of SREBP Improves Cardiac...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Inhibition of SREBP Improves Cardiac...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Cardiomyopathies › Cardiomyopathie associée à la maladie de Chagas › Inhibition of SREBP Improves Cardiac...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Inhibition of SREBP Improves Cardiac...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Inhibition of SREBP Improves Cardiac...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Stress du réticulum endoplasmique › Inhibition of SREBP Improves Cardiac...
questionsmedicales.fr › Phénomènes biologiques › Interactions hôte-microbes › Interactions hôte-pathogène › Interactions hôte-parasite › Inhibition of SREBP Improves Cardiac...
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › Inhibition of SREBP Improves Cardiac...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C3H › Inhibition of SREBP Improves Cardiac...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Inhibition of SREBP Improves Cardiac...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Inhibition of SREBP Improves Cardiac...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteurs de transcription à motifs basiques hélice-boucle-hélice et à glissière à leucines › Protéines de liaison à l'élément de régulation des stérols › Inhibition of SREBP Improves Cardiac...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Triterpènes › Inhibition of SREBP Improves Cardiac...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Trypanosoma › Trypanosoma cruzi › Inhibition of SREBP Improves Cardiac...