Phase separation provides a mechanism to reduce noise in cells.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
24 01 2020
24 01 2020
Historique:
received:
19
10
2018
revised:
18
09
2019
accepted:
06
12
2019
entrez:
25
1
2020
pubmed:
25
1
2020
medline:
22
4
2020
Statut:
ppublish
Résumé
Expression of proteins inside cells is noisy, causing variability in protein concentration among identical cells. A central problem in cellular control is how cells cope with this inherent noise. Compartmentalization of proteins through phase separation has been suggested as a potential mechanism to reduce noise, but systematic studies to support this idea have been missing. In this study, we used a physical model that links noise in protein concentration to theory of phase separation to show that liquid droplets can effectively reduce noise. We provide experimental support for noise reduction by phase separation using engineered proteins that form liquid-like compartments in mammalian cells. Thus, phase separation can play an important role in biological signal processing and control.
Identifiants
pubmed: 31974256
pii: 367/6476/464
doi: 10.1126/science.aav6691
doi:
Substances chimiques
Bacterial Proteins
0
Luminescent Proteins
0
Recombinant Proteins
0
yellow fluorescent protein, Bacteria
0
DDX4 protein, human
EC 3.6.1.-
DEAD-box RNA Helicases
EC 3.6.4.13
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
464-468Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.