Transcriptional regulation of the IL-13Rα2 gene in human lung fibroblasts.
Cyclic AMP-Dependent Protein Kinases
/ genetics
Dinoprostone
/ metabolism
Fibroblasts
/ metabolism
Gene Expression Regulation
Humans
Interleukin-13
/ genetics
Interleukin-13 Receptor alpha2 Subunit
/ genetics
Lung
/ cytology
Proto-Oncogene Proteins c-akt
/ genetics
Signal Transduction
Transcription, Genetic
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
23 01 2020
23 01 2020
Historique:
received:
27
09
2019
accepted:
20
12
2019
entrez:
25
1
2020
pubmed:
25
1
2020
medline:
20
11
2020
Statut:
epublish
Résumé
Interleukin (IL)-13 is a type 2 cytokine with important roles in allergic diseases, asthma, and tissue fibrosis. Its receptor (R) α1 is primarily responsible for the biological actions of this cytokine, while Rα2 possesses a decoy function which can block IL-13 signaling. Although the expression of Rα2 is known to be subject to modulation, information about its transcriptional regulation is limited. In this study, we sought to expand the understanding of transcriptional control of Rα2 in lung fibroblasts. We confirmed previous reports that IL-13 elicited modest induction of Rα2 in normal adult human lung fibroblasts, but found that prostaglandin E
Identifiants
pubmed: 31974428
doi: 10.1038/s41598-020-57972-1
pii: 10.1038/s41598-020-57972-1
pmc: PMC6978327
doi:
Substances chimiques
Interleukin-13
0
Interleukin-13 Receptor alpha2 Subunit
0
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Cyclic AMP-Dependent Protein Kinases
EC 2.7.11.11
Dinoprostone
K7Q1JQR04M
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1083Subventions
Organisme : NHLBI NIH HHS
ID : R35 HL144979
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI129958
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL125555
Pays : United States
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